Crystal structure of hRANKL-mRANK complex

A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis.

Tumor necrosis factor ligand superfamily member 11

Tumor necrosis factor receptor superfamily member 11A

Osteoclast differentiation factor,ODF,Osteoprotegerin ligand,OPGL,Receptor activator of nuclear factor kappa-B ligand,RANKL,TNF-related activation-induced cytokine,TRANCE

Osteoclast differentiation factor receptor,ODFR,Receptor activator of NF-KB, RANK

SKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQ
LMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID

MGSSHHHHHHSSGLVPRGSHMHMQVTLQVTPPCTQERHYEHLGRCCSRCEPGKYLSSKCTPTSDSVCLPCGPDEYLDTWN
EEDKCLLHKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNSDCECCRRNTECAPGFGAQHPLQLNKDTVCTPCLLGFFSD
VFSSTDKCKPWTNCTLLGKLEAHQGTTESDVVCSSSMTLRRPPKEAQALEHHHHHH

0.1 M sodium di-hydrogen phosphate, 2 M sodium chloride, 0.1 M potassium di-hydrogen phosphate and 0.1 M MES

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

RANK, RANKL, RANKL-RANK complex, TNFSF11, TNFRSF11a, TNF superfamily, cytokine

QVTLQVTPPCTQERHYEHLGRCCSRCEPGKYLSSKCTPTSDSVCLPCGPDEYLDTWNEEDKCLLHKVCDAGKALVAVDPG
NHTAPRRCACTAGYHWNSDCECCRRNTECAPGFGAQHPLQLNKDTVCTPCLLGFFSDVFSSTDKCKPWTNCTLLGKLEAH
QGTTESDVVCSSSMTLRRPPKEAQA