Crystal Structure of cytidine monophosphate hydroxymethylase MilA with CMP

Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis

TFGTFQDAYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHISVPARRANVVFNFAEALWYLSGSDRLDFIQY
YAPGIAAYSADGRTLRGTAYGPRIFRHPAGGVNQWENVVKTLTDDPDSKRAVIQIFDPRELAVADNIDVACTLALQFLIR
DGLLCGIGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLGIGTYHHVVGSVHIYDSDARWAERVLDAATPDGGPRPGFPA
MPDGDNWPHVRRVLEWEERLRTNAARLSADALDALDLPAYWKHVVALFEAHRQVRHEDTPDRALLAALPEVYRQSLAVKW
PGHFG

0.1 M sodium cacodylate trihydrate(pH 6.5), 1.4 M sodium acetate trihydrate