Crystal structure of in vitro phosphorylated human SAMHD1 (amino acid residues 115-626) bound to GTP

Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.

DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1

DNTPASE, DENDRITIC CELL-DERIVED IFNG-INDUCED PROTEIN, DCIP, MONOCYTE PROTEIN 5, MOP-5, SAM DOMAIN AND HD DOMAIN-CONTAINING PR OTEIN 1, DNTPASE, DENDRITIC CELL-DERIVED IFNG-INDUCED PROTEIN, DCI P, MONOCYTE PROTEIN 5, MOP-5, SAM DOMAIN AND HD DOMAIN-CONTAINING PR OTEIN 1, SAMHD1

MASWSHPQFEKGALEVLFQGPGYQDPMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHS
LGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSN
GIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN
FDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYR
ISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVL
LDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWNDSTSVQNPTRLREASKSRVQLFKDDPM

CRYSTAL STRUCTURE OF HUMAN SAMHD1 (AMINO ACID RESIDUES 41-583) BOUND TO DDGTP

CRYSTAL STRUCTURE OF HUMAN SAMHD1 (AMINO ACID RESIDUES 115-583) BOUND TO DDGTP

CRYSTAL STRUCTURE OF HUMAN SAMHD1 (AMINO ACID RESIDUES 115-583) R164A VARIANT BOUND TO DGTP

CRYSTAL STRUCTURE OF HUMAN SAMHD1 (AMINO ACID RESIDUES 115-626) BOUND TO GTP

HYDROLASE, DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE, HIV RESTRICTION FACTOR