Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13

N-acetyl-alpha-D-galactosamine; 2-acetamido-2-deoxy-alpha-D-galactose; 2-acetamido-2-deoxy-D-galactose; 2-acetamido-2-deoxy-galactose; N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE

Dynamic Interplay between Catalytic and Lectin Domains of Galnac-Transferases Modulates Protein O-Glycosylation.

POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2

POLYPEPTIDE GALNAC TRANSFERASE 2, GALNAC-T2, PP-GANTASE 2, PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE 2, UDP-GALNAC\:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 SOLUBLE FORM

MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPD
FNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVL
KKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLER
VAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEE
LGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAV
PSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQ
EWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCREDDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALS
QQWKFTLNLQQ

CRYSTAL STRUCTURE OF THE INACTIVE FORM OF GALNAC-T2 IN COMPLEX WITH THE GLYCOPEPTIDE MUC5AC-CYS13

CRYSTAL STRUCTURE OF THE INACTIVE FORM OF GALNAC-T2 IN COMPLEX WITH THE GLYCOPEPTIDE MUC5AC-3,13

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

TRANSFERASE, GALNAC-T2, AFM, SAXS, LECTIN DOMAIN, COARSE-GRAINED MODEL, GLYCOPEPTIDES, INACTIVE FORM, ACTIVE FORM, COMPACT FORM, EXTENDED FORM