Crystal structure of the LeuRS editing domain of Candida albicans Mutant K510A in complex with the adduct formed by AN2690-AMP

[(6-AMINO-9H-PURIN-9-YL)-[5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE]-4'YL]METHYL DIHYDROGEN PHOSPHATE

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight Into the Leucyl-tRNA Synthetase Editing Mechanism.

POTENTIAL CYTOSOLIC LEUCYL TRNA SYNTHETASE
EDITING DOMAIN (CP1), UNP RESIDUES 280-530

MGYVGIKIRLTDVAPQAQELFKKESLDVKENKVYLVAATLRPETMYGQTCCFVSPKIDYGVFDAGNGDYFITTERAFKNM
SFQNLTPKRGYYKPLFTINGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSPDDFVTTRDLANKPEYYG
IEKDWVQTDIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLANAKELAYKEGFYNGTMLIGKYKGDKVEDAAPKVKQDL
IDEGLAFVYNEPELEHHHHHH

0.2 M SODIUM ACETATE, 0.1 M HEPES SODIUM PH 7.4, 30% PEG 2000

CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF CANDIDA ALBICANS MUTANT K510A

CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF CANDIDA ALBICANS IN COMPLEX WITH THE ADDUCT AN2690-AMP

CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF AGROBACTERIUM RADIOBACTER K84 AGNB2 LEURS-TRNA-LEUAMS

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES REFINED INDIVIDUALLY

LIGASE, AMINOACYL-TRNA SYNTHETASE, AMINOACYLATION, PROTEIN SYNTHESIS, PROOF-READING MECHANISMS, ANTIFUNGAL TARGET