VIM-2-2, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening

Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening

MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDEL
LLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSS
SGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGG(OCS)AIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFV
IPGHGLPGGLDLLKHTTNVVKAHTNRSVVE

MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDEL
LLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSS
SGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGH
GLPGGLDLLKHTTNVVKAHTNRSVVE

22-27% PEG 3350, 0.2 M MAGNESIUM FORMATE, 5 MM BETA-MERCAPTOETHANOL, pH 7.2

VIM-2-NAT, DISCOVERY OF NOVEL INHIBITOR SCAFFOLDS AGAINST THE METALLO-BETA-LACTAMASE VIM-2 BY SPR BASED FRAGMENT SCREENING

VIM-2-1, DISCOVERY OF NOVEL INHIBITOR SCAFFOLDS AGAINST THE METALLO-BETA-LACTAMASE VIM-2 BY SPR BASED FRAGMENT SCREENING