Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6

The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.

Advanced glycosylation end product-specific receptor
V, C1 and C2 domains (VC1C2 module), full-length ectodomain, UNP residues 23-323

Receptor for advanced glycosylation end products

Calcyclin,Growth factor-inducible protein 2A9,MLN 4,Prolactin receptor-associated protein,PRA,S100 calcium-binding protein A6

GAMAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRC
QAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRR
HPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTC
EVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEP

GAMACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLG
ALALIYNEALKG

0.2 M Zn acetate, 0.1 M Na cacodylate pH 6.5, 10% isopropanol

4P2Y represents the structure of the complex between human RAGE ectodomain and mouse S100A6

signaling complex, pattern recognition receptor, dimerization, EF-hand calcium binding protein, immunoglobulin domain, signaling protein

AQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAM
NRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPE
TGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVP
AQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEP

MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGAL
ALIYNEALKG