Crystal structure of the di-domain ARO/CYC StfQ from the steffimycin biosynthetic pathway

Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.

MGSSHHHHHHSSGLVPRGSHMPTLGKDTLQYTATVAAPAPLVFDLVAGLENWPQFHGPSVHAEPLGRRDGAEEFQHWWVI
DDRTVRTWRARWRFDSQALRIGYTYDPAEPAAPAQHGEWTFRRLSDASTEVRVEYELLGDEGDAALADRELRELVDCVTD
AAERHEERRDLVVDFEDPLFVAGAVDDAYTYLYEADKWPERIPHVARLVMEERVPNIQFFDMDTTTPDGSAHTTRSVRVC
LPGDKIVYKQIQLPKLLTGHTGHWKFTPTREGFVLGARHTATIKPSALPILGEGTTVLDARKYLRRVLSANSMGNLRLAK
AFAEERAGV

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Crystal structure of Zhui aromatase/cyclase from Streptomyces sp. R1128

Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens

Solution NMR structure of Streptomyces coelicolor polyketide cyclase SCO5315

aromatase/cyclase, helix-grip fold, polyketide, polyketide synthase, natural products, dehydratase, ARO/CYC, LYASE

MPTLGKDTLQYTATVAAPAPLVFDLVAGLENWPQFHGPSVHAEPLGRRDGAEEFQHWWVIDDRTVRTWRARWRFDSQALR
IGYTYDPAEPAAPAQHGEWTFRRLSDASTEVRVEYELLGDEGDAALADRELRELVDCVTDAAERHEERRDLVVDFEDPLF
VAGAVDDAYTYLYEADKWPERIPHVARLVMEERVPNIQFFDMDTTTPDGSAHTTRSVRVCLPGDKIVYKQIQLPKLLTGH
TGHWKFTPTREGFVLGARHTATIKPSALPILGEGTTVLDARKYLRRVLSANSMGNLRLAKAFAEERAGV