Crystal Structure of Human Adenovirus 52 Short Fiber Knob in Complex with 2-O-Methyl-5-N-Acetylneuraminic Acid

2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid
2-O-METHYL-5-N-ACETYL-ALPHA-D- NEURAMINIC ACID

Human Adenovirus 52 Uses Sialic Acid-containing Glycoproteins and the Coxsackie and Adenovirus Receptor for Binding to Target Cells.

His-tagged knob domain of short fiber (fiber-1)

MRGSHHHHHHGSGSGSGIEGRPYNGTGSRFNSSGAIAFGIQTLWTPPTSNPNCTVYTESDSLLSLCLTKCGAHVLGSVSL
TGVAGTMTNMAETSLAIEFTFDDTGKLLHSPLVNNTFSIRQGDSPASNPTYNALAFMPNSTLYARGGSGEPRNNYYVQTY
LRGNVQRPITLTVTFNSAATGYSLSFKWTAVVREKFAAPATSFCYITEQ

15% (w/V) PEG1000, 12.5% (w/V) PEG3350, 12.5% (w/V) MPD, 0.02 mM of each Na L glutamate, DL alanine, glycine, DL lysine HCl, and DL serine, 0.1 M Tris/Bicine

2-O-methyl-5-N-acetyl-a-D-neuraminic acid

viral protein, sialic acid, viral attachment, fiber knob, protein carbohydrate interaction

RFNSSGAIAFGIQTLWTPPTSNPNCTVYTESDSLLSLCLTKCGAHVLGSVSLTGVAGTMTNMAETSLAIEFTFDDTGKLL
HSPLVNNTFSIRQGDSPASNPTYNALAFMPNSTLYARGGSGEPRNNYYVQTYLRGNVQRPITLTVTFNSAATGYSLSFKW
TAVVREKFAAPATSFCYITEQ