Crystal structure of the 16S rRNA (adenine(1408)-N(1))-methyltransferase from Catenulisporales acidiphilia

Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization.

16S rRNA (adenine(1408)-N(1))-methyltransferase

MHHHHHHASGLVPRGSHMTRTTALKVLAGKKLTDLDPDEWAKAQASAERILVDVGTGDARTAYRQAIAHPEWLVVGVDPA
WQRMTETAVRAARKPAKGGAPNLVLVSSAIETVPAALHGVADEVMVLMPWGKLLRGVVLGEADVLSGLRAVAKPGAPLEI
SIGTSIWREPIPLEIRDLPELTPETVVSTGLTDRLAALGWQVADVRLVPHTDLDTISSSWARRLGSGATETVLHLRAVAV
DPRDPVGTQHPAAESAQDTPEEPQRDV

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

methyltransferase, ribosome, aminoglycoside resistance, TRANSFERASE

MTRTTALKVLAGKKLTDLDPDEWAKAQASAERILVDVGTGDARTAYRQAIAHPEWLVVGVDPAWQRMTETAVRAARKPAK
GGAPNLVLVSSAIETVPAALHGVADEVMVLMPWGKLLRGVVLGEADVLSGLRAVAKPGAPLEISIGTSIWREPIPLEIRD
LPELTPETVVSTGLTDRLAALGWQVADVRLVPHTDLDTISSSWARRLGSGATETVLHLRAVAVDPRDPVGTQHPAAESAQ
DTPEEPQRDV