Crystal Structure of mUCH37-hRPN13 CTD-hUb complex

Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase.

Ubiquitin carboxyl-terminal hydrolase isozyme L5

UCH-L5,Ubiquitin C-terminal hydrolase UCH37,Ubiquitin thioesterase L5

110 kDa cell membrane glycoprotein,Gp110,Adhesion-regulating molecule 1,ARM-1,Proteasome regulatory particle non-ATPase 13,hRpn13,Rpn13 homolog

MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFA
KQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEE
DAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQR
QLAEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQN
AKKAQETK

QVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAE
AVEAANKGDVEAFAKAMQNNAK

25% PEG 3350, 220 mM MgCl2,100 mM Bis-Tris

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

National Institutes of Health/National Cancer Institute (NIH/NCI)

National Institutes of Health/National Center for Research Resources (NIH/NCRR)

Department of Energy (DOE, United States)

UCH37 RPN13 Proteasome INO80 DUB, PROTEIN BINDING