Crystal structure of E.Coli DsbA soaked with compound 4

4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid

Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA.

DOUBLE SI WITH SAGITTALY BENT SECOND CRYSTAL

AQYEDGKQYTTLEKPVAGAPQVLEFFSFFCPHCYQFEEVLHISDNVKKKLPEGVKMTKYHVNFMGGDLGKDLTQAWAVAM
ALGVEDKVTVPLFEGVQKTQTIRSASDIRDVFINAGIKGEEYDAAWNSFVVKSLVAQQEKAAADVQLRGVPAMFVNGKYQ
LNPQGMDTSNMDVFVQQYADTVKYLSEKK

11-13% PEG 8000, 5-7.5% glycerol, 1 mM CuCl2, 100 mM sodium cacodylate

National Health and Medical Research Council (Australia)

DISULFIDE OXIDOREDUCTASE, REDOX PROTEIN, DSBA, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex