Mouse Galactocerebrosidase complexed with iso-galacto-fagomine IGF

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.

GALCERASE, GALACTOCEREBROSIDE BETA-GALACTOSIDASE, GALACTOSYLCERAMIDASE, GALACTOSYLCERAMIDE BETA-GALACTOSIDASE

HHHHHHIEGRGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSEILDYLFKPNFGASLHILKVEIGGDGQTTD
GTEPSHMHYELDENYFRGYEWWLMKEAKKRNPDIILMGLPWSFPGWLGKGFSWPYVNLQLTAYYVVRWILGAKHYHDLDI
DYIGIWNERPFDANYIKELRKMLDYQGLQRVRIIASDNLWEPISSSLLLDQELWKVVDVIGAHYPGTYTVWNAKMSGKKL
WSSEDFSTINSNVGAGCWSRILNQNYINGNMTSTIAWNLVASYYEELPYGRSGLMTAQEPWSGHYVVASPIWVSAHTTQF
TQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHQHSMCIRPYLPYYNVSHQLATFTLKGSLREIQELQVWYTKL
GTPQQRLHFKQLDTLWLLDGSGSFTLELEEDEIFTLTTLTTGRKGSYPPPPSSKPFPTNYKDDFNVEYPLFSEAPNFADQ
TGVFEYYMNNEDREHRFTLRQVLNQRPITWAADASSTISVIGDHHWTNMTVQCDVYIETPRSGGVFIAGRVNKGGILIRS
ATGVFFWIFANGSYRVTADLGGWITYASGHADVTAKRWYTLTLGIKGYFAFGMLNGTILWKNVRVKYPGHGWAAIGTHTF
EFAQFDNFRVEAAR

0.2 M SODIUM ACETATE, 0.1 M SODIUM CACODYLATE (PH 6.8), 34% PEG 8000

MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH AZA-GALACTO- FAGOMINE AGF

MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH ISO-GALACTO- FAGOMINE LACTAM IGL

MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH DIDEOXY-IMINO- LYXITOL DIL

MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH DEOXY-GALACTO- NOEUROSTEGINE DGN

MOUSE GALACTOCEREBROSIDASE COMPLEXED WITH 1-DEOXY-GALACTO -NOJIRIMYCIN DGJ

SHEET
DETERMINATION METHOD: DSSP
THE SHEETS PRESENTED AS "AD" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY
A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.

NUMBERING IS FROM SECOND START SITE AS USED IN THE LITERATURE AND IN PDB ENTRIES 3ZR5, 3ZR6, 4CCC, 4CCD, 4CCE.

CHAIN 'A' AND ((RESSEQ 25:40) OR (RESSEQ 338:452))

HYDROLASE, GLYCOSYL HYDROLASE, COMPLEX, LYSOSOME