X-ray crystal structure of CYP119 from Sulfolobus acidocaldarius, complexed with 4-(4-chlorophenyl)imidazole

NMR and X-ray Analysis of CYP119 Ligand Dependent Conformational Changes.

MYDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKIRFDIPTRYTMLTSDPPLHDELR
SMSADIFSPQKLQTLETFIRETTRSLLDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKFKEWSDLVAFRLGKPGE
IFELGKKYLELIGYVKDHLNSGTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRFNLWQRIREENLY
LKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDRNPNPHLSFGSGIHLCLGA
PLARLEARIAIEEFSKRFRHIEILDTEKVPNEVLNGYKRLVVRLKSNE

1.1-1.5M Ammonium sulfate, 80mM sodium acetate pH 4.5, 20mM sodium acetate pH 5.6, 20% glycerol, 340mM NaCl

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

4TT5 is the same protein complexed with 4-4-(4-Bromophenyl)-1H-imidazole