A Carbonic Anhydrase IX Mimic in Complex with Saccharin

1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE

Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.

Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II

MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLK
GGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVV
DVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK

1.6 M sodium citrate, 50 mM Tris, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K

Carbonic Anhydrase Fold, Reversible Hydration of CO2, Active Site Point Mutations, Cytosolic, Lyase

MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLK
GGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVV
DVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK