Vvtgvta, an amyloid forming segment from alpha synuclein, residues 70-76
Structure-based design of functional amyloid materials.
Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP
isopropanol, sodium cacodylate, pH 6.5, vapor diffusion, hanging drop, temperature 298K
TGVTAVA, another amyloid forming segment from alpha-synuclein
VVTGVTA (residues 70-76) from Human alpha-synuclein, synthesized
HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
The biological unit is a fibril, comprising a pair of beta sheets constructed from chain A and unit cell translations along the b direction (that is, the b direction corresponds to the fiber axis) (i.e. X,Y,Z; X,Y+1,Z; X,Y+2,Z; etc.) together with a symmetry related sheet formed from 1/2-X,1/2+Y,-Z+1 and its unit cell translations along the b direction (i.e. 1/2-X,3/2+Y,-Z+1; 1/2-X,5/2+Y,-Z+1; etc.). REMARK 350 displays 5 strands from each sheet.
amyloid-like protofibril, PROTEIN FIBRIL