Crystal structure of the complex between IL-13 and M1295 FAB

Human Framework Adaptation of a Mouse Anti-Human Il-13 Antibody.

EIVLTQSPATLSLSPGERATLSCRASKSISKYLAWYQQKPGQAPRLLIYSGSTLQSGIPARFSGSGSGTDFTLTISSLEP
EDFAVYYCQQHDYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE
SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

(PCA)VTLKESGPVLVKPTETLTLTCTVSGFSLSTYGVGVGWIRQPPGKALEWLAHIWWDDVKRYNPALKSRLTISKDTS
KSQVVLTMTNMDPVDTATYYCARLGSDYDVWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE
PVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH

QVTLKESGPVLVKPTETLTLTCTVSGFSLSTYGVGVGWIRQPPGKALEWLAHIWWDDVKRYNPALKSRLTISKDTSKSQV
VLTMTNMDPVDTATYYCARLGSDYDVWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH

MGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQF
SSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

0.1 M SODIUM ACETATE PH 4.5, 25% PEG 8K, VAPOR DIFFUSION, SITTING DROP, temperature 293K

IMMUNOGLOBULIN FOLD, ALPHA-HELICAL BUNDLE, CYTOKINE, DISULFIDE BOND, GLYCOPROTEIN, SECRETED, MONOCLONAL ANTIBODY, IMMUNE SYSTEM

GPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFS
SLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN