Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor

Discovery and structure-based optimization of adenain inhibitors.

Adenain,Adenovirus protease,AVP,Adenovirus proteinase,Endoprotease

MGSSEQELKAIVKDLGCGPYFLGTYDKRFPGFVSPHKLACAIVNTAGRETGGVHWMAFAWNPRSKTCYLFEPFGFSDQRL
KQVYQFEYESLLRRSAIASSPDRCITLEKSTQSVQGPNSAACGLFCCMFLHAFANWPQTPMDHNPTMNLITGVPNSMLNS
PQVQPTLRRNQEQLYSFLERHSPYFRSHSAQIRSATSFCHLKNM

0.8 M sodium/potassium tartrate, 0.1 M HEPES pH 7.5

1NLN contains the uninhibited adenovirus 2 protease.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

Adenain, cysteine protease, adenovirus, pVIc cofactor, virus maturation, Hydrolase-Hydrolase Inhibitor complex