Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.

GMSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCER
FTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNI
ATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLA
FKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHE
ESILERVQQHIESKLLGSNSSRMYFTQT

20% PEG4000, 10% ISOPROPANOL, 0.1 M HEPES

This entry is a re-interpretation of the data underlying entry 3NA3.

This entry is a re-interpretation of the data underlying entry 3NA3. Autobuster was used during intermediate refinement steps. COOT was used for interactive model building. Model geometry was evaluated with MOLPROBITY.

has not been determined as part of this study.

structural genomics consortium, DNA MISMATCH REPAIR, DNA DAMAGE, SGC, DNA binding protein

MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERF
TTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIA
TRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAF
KMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEE
SILERVQQHIESKLLGSNSSRMYFTQT