Crystal structure of ThiT with small molecule BAT-25

Beta-NONYLGLUCOSIDE; nonyl beta-D-glucoside; nonyl D-glucoside; nonyl glucoside

Crystal structure of ThiT with small molecules modulators

liquid nitrogen cooled channel-cut Si(111)

Thiamine ECF transporter S component ThiT

MHHHHHHHHAMSNSKFNVRLLTEIAFMAALAFIISLIPNTVYGWIIVEIACIPILLLSLRRGLTAGLVGGLIWGILSMIT
GHAYILSLSQAFLEYLVAPVSLGIAGLFRQKTAPLKLAPVLLGTFVAVLLKYFFHFIAGIIFWSQYAWKGWGAVAYSLAV
NGISGILTAIAAFVILIIFVKKFPKLFIHSNY

0.15 M ammonium nitrate, 20% PEG3350, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 278K

Structure of ThiT with native substrate bound

S-component, ECF transporter, ABC transporter, substrate binding domain for thiamin, TRANSPORT PROTEIN, THIAMINE BINDING PROTEIN

MSNSKFNVRLLTEIAFMAALAFIISLIPNTVYGWIIVEIACIPILLLSLRRGLTAGLVGGLIWGILSMITGHAYILSLSQ
AFLEYLVAPVSLGIAGLFRQKTAPLKLAPVLLGTFVAVLLKYFFHFIAGIIFWSQYAWKGWGAVAYSLAVNGISGILTAI
AAFVILIIFVKKFPKLFIHSNY