The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER

Rosenbaum-Rock double-crystal monochromator

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK

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0.1M Tris-HCl, 0.2M calcium chloride, 25% PEG 4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K

FOLATE BIOSYNTHESIS, Diphosphotransferases, PTERIN, ATP binding, Inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

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