X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 3 nucleobase

Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer.

Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain

Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin heavy chain

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVL
QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY
THVFRLKKWIQKVIDQFGE

60% Tacsimate, 1-3% MPEG 5K or PEG 8000, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Thrombin light chain (E.C.3.4.21.5), Thrombin heavy chain (E.C.3.4.21.5)

PROTEIN-DNA COMPLEX, DNA APTAMER, G-QUADRUPLEX, TBA DELETION MUTANT, Serine protease, Hydrolase, Blood coagulation, Blood, HYDROLASE-DNA complex, HYDROLASE-HYDROLASE INHIBITOR-DNA complex