Bcl_2-Navitoclax Analog (without Thiophenyl) Complex

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.

MAHPGRTGYDNREIVMKYIHYKLSQRGYEWDAGDDVEENRTEAPEGTESEVVHLTLRQAGDDFSRRYRRDFAEMSSQLHL
TPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVEL
YGPSMR

1.5 M (NH4)2SO4, 0.1 M MES, 8%(V/V) PEG400, pH 6.5, VAPOR DIFFUSION, temperature 296K

8 helices, APOPTOSIS REGULATOR-INHIBITOR complex

VVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVD
NIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMR