Crystal structure of a Cdc6 phosphopeptide in complex with Cks1

Cks confers specificity to phosphorylation-dependent CDK signaling pathways.

Cyclin-dependent kinases regulatory subunit
Cyclin-dependent kinases regulatory subunit (unp residues 1-113)

MYHHYHAFQGRKLTDQERARVLEFQDSIHYSPRYSDDNYEYRHVMLPKAMLKVIPSDYFNSEVGTLRILTEDEWRGLGIT
QSLGWEHYECHAPEPHILLFKRPLNYEAELRAAIPI(TPO)PT

MYHHYHAFQGRKLTDQERARVLEFQDSIHYSPRYSDDNYEYRHVMLPKAMLKVIPSDYFNSEVGTLRILTEDEWRGLGIT
QSLGWEHYECHAPEPHILLFKRPLNYEAELRAAIPITPT

400mM potassium sodium tartrate, 0.1M MES, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K

TRANSFERASE REGULATOR, Phospho-protein, PROTEIN BINDING

MYHHYHAFQGRKLTDQERARVLEFQDSIHYSPRYSDDNYEYRHVMLPKAMLKVIPSDYFNSEVGTLRILTEDEWRGLGIT
QSLGWEHYECHAPEPHILLFKRPLNYEAELRAA