4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes

NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

(4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide

1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11-HSD1 inhibitors for the treatment of diabetes.

Corticosteroid 11-beta-dehydrogenase isozyme 1

11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1

MKHQHQHQHQHQHQQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASA
HYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIV
VVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEII
KGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRFINK

40% PEG300, 0.1M MES, pH 6.5, vapor diffusion, temperature 277K, VAPOR DIFFUSION, HANGING DROP

11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1, short chain dehydrogenase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

NEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV
AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY
SASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLW
TTLLIRNPCRKILEFLYSTSYNMDRFINK