Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
type: datablock
alternative label: 4JVE
link to mmcif: 4JVE.cif.gz
link to pdbml: 4JVE.xml.gz
link to pdbml noatom: 4JVE-noatom.xml.gz
link to pdbml extatom: 4JVE-extatom.xml.gz
link to doi: doi:10.2210/pdb4JVE/pdb
datablock name: 4JVE-noatom
has atom sites category: atom sitesCategory
has atom type category: atom typeCategory
has audit author category: audit authorCategory
has audit conform category: audit conformCategory
has cell category: cellCategory
has chem comp category: chem compCategory
has citation category: citationCategory
has citation author category: citation authorCategory
has database 2 category: database 2Category
has database PDB matrix category: database PDB matrixCategory
has diffrn category: diffrnCategory
has diffrn detector category: diffrn detectorCategory
has diffrn radiation category: diffrn radiationCategory
has diffrn radiation wavelength category: diffrn radiation wavelengthCategory
has diffrn source category: diffrn sourceCategory
has entity category: entityCategory
has entity name com category: entity name comCategory
has entity poly category: entity polyCategory
has entity poly seq category: entity poly seqCategory
has entity src gen category: entity src genCategory
has entry category: entryCategory
has exptl category: exptlCategory
has exptl crystal category: exptl crystalCategory
has exptl crystal grow category: exptl crystal growCategory
has pdbx audit revision details category: pdbx audit revision detailsCategory
has pdbx audit revision group category: pdbx audit revision groupCategory
has pdbx audit revision history category: pdbx audit revision historyCategory
has pdbx database related category: pdbx database relatedCategory
has pdbx database status category: pdbx database statusCategory
has pdbx entity nonpoly category: pdbx entity nonpolyCategory
has pdbx nonpoly scheme category: pdbx nonpoly schemeCategory
has pdbx poly seq scheme category: pdbx poly seq schemeCategory
has pdbx struct assembly category: pdbx struct assemblyCategory
has pdbx struct assembly gen category: pdbx struct assembly genCategory
has pdbx struct oper list category: pdbx struct oper listCategory
has pdbx struct sheet hbond category: pdbx struct sheet hbondCategory
has pdbx unobs or zero occ residues category: pdbx unobs or zero occ residuesCategory
has pdbx validate torsion category: pdbx validate torsionCategory
has pdbx xplor file category: pdbx xplor fileCategory
has refine category: refineCategory
has refine hist category: refine histCategory
has refine ls restr category: refine ls restrCategory
has reflns category: reflnsCategory
has reflns shell category: reflns shellCategory
has software category: softwareCategory
has struct category: structCategory
has struct asym category: struct asymCategory
has struct biol category: struct biolCategory
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has struct conf type category: struct conf typeCategory
has struct conn category: struct connCategory
has struct conn type category: struct conn typeCategory
has struct keywords category: struct keywordsCategory
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has struct ref seq category: struct ref seqCategory
has struct ref seq dif category: struct ref seq difCategory
has struct sheet category: struct sheetCategory
has struct sheet order category: struct sheet orderCategory
has struct sheet range category: struct sheet rangeCategory
has struct site category: struct siteCategory
has struct site gen category: struct site genCategory
has symmetry category: symmetryCategory

4JVE
type: atom sites
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
atom sites.entry id: 4JVE
atom sites.fract transf matrix11: 0.023802
atom sites.fract transf matrix12: 0
atom sites.fract transf matrix13: 0
atom sites.fract transf matrix21: 0
atom sites.fract transf matrix22: 0.023802
atom sites.fract transf matrix23: 0
atom sites.fract transf matrix31: 0
atom sites.fract transf matrix32: 0
atom sites.fract transf matrix33: 0.008374
atom sites.fract transf vector1: 0
atom sites.fract transf vector2: 0
atom sites.fract transf vector3: 0

4JVE
referenced by atom sites: 4JVE
referenced by cell: 4JVE
referenced by database PDB matrix: 4JVE
type: entry
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
entry.id: 4JVE
referenced by exptl: 4JVE,X-RAY DIFFRACTION
referenced by refine: 4JVE,X-RAY DIFFRACTION
referenced by reflns: http://rdf.wwpdb.org/pdb/4JVE/reflns/1
referenced by struct: 4JVE
referenced by struct keywords: 4JVE
referenced by symmetry: 4JVE
referenced by pdbx database status: 4JVE

http://rdf.wwpdb.org/pdb/4JVE/atom_type/C
type: atom type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
atom type.symbol: C

CL
type: atom type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
atom type.symbol: CL

http://rdf.wwpdb.org/pdb/4JVE/atom_type/F
type: atom type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
atom type.symbol: F

http://rdf.wwpdb.org/pdb/4JVE/atom_type/N
type: atom type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
atom type.symbol: N

http://rdf.wwpdb.org/pdb/4JVE/atom_type/O
type: atom type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
atom type.symbol: O

http://rdf.wwpdb.org/pdb/4JVE/atom_type/S
type: atom type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
atom type.symbol: S

http://rdf.wwpdb.org/pdb/4JVE/audit_author/1
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 1
audit author.name: Huang, X.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/2
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 2
audit author.name: Gonzalez-Lopez de Turiso, F.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/3
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 3
audit author.name: Sun, D.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/4
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 4
audit author.name: Yosup, R.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/5
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 5
audit author.name: Bartberger, M.D.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/6
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 6
audit author.name: Beck, H.P.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/7
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 7
audit author.name: Cannon, J.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/8
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 8
audit author.name: Shaffer, P.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/9
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 9
audit author.name: Oliner, J.D.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/10
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 10
audit author.name: Olson, S.H.

http://rdf.wwpdb.org/pdb/4JVE/audit_author/11
type: audit author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit author.pdbx ordinal: 11
audit author.name: Medina, J.C.

mmcif pdbx.dic,5.281
type: audit conform
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
audit conform.dict name: mmcif_pdbx.dic
audit conform.dict version: 5.281
audit conform.dict location: http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic

4JVE
type: cell
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
cell.entry id: 4JVE
cell.z PDB: 8
cell.angle alpha: 90
cell.angle beta: 90
cell.angle gamma: 90
cell.length a: 42.014
cell.length b: 42.014
cell.length c: 119.418

1MQ
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: 1MQ
chem comp.formula: C28 H24 Cl2 F N O4
chem comp.formula weight: 528.399
chem comp.name: (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.type: non-polymer
link to chem comp: 1MQ

ALA
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: ALA
chem comp.formula: C3 H7 N O2
chem comp.formula weight: 89.093
chem comp.mon nstd flag: y
chem comp.name: ALANINE
chem comp.type: L-peptide linking
link to chem comp: ALA
referenced by entity poly seq: 1,ALA,26
referenced by entity poly seq: 1,ALA,4

ARG
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: ARG
chem comp.formula: C6 H15 N4 O2 1
chem comp.formula weight: 175.209
chem comp.mon nstd flag: y
chem comp.name: ARGININE
chem comp.type: L-peptide linking
link to chem comp: ARG
referenced by entity poly seq: 1,ARG,88
referenced by entity poly seq: 1,ARG,12
referenced by entity poly seq: 1,ARG,48
referenced by entity poly seq: 1,ARG,80

ASN
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: ASN
chem comp.formula: C4 H8 N2 O3
chem comp.formula weight: 132.118
chem comp.mon nstd flag: y
chem comp.name: ASPARAGINE
chem comp.type: L-peptide linking
link to chem comp: ASN
referenced by entity poly seq: 1,ASN,94
referenced by pdbx unobs or zero occ residues: http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/2
referenced by entity poly seq: 1,ASN,62
referenced by entity poly seq: 1,ASN,89

ASP
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: ASP
chem comp.formula: C4 H7 N O4
chem comp.formula weight: 133.103
chem comp.mon nstd flag: y
chem comp.name: ASPARTIC ACID
chem comp.type: L-peptide linking
link to chem comp: ASP
referenced by entity poly seq: 1,ASP,67
referenced by entity poly seq: 1,ASP,29
referenced by entity poly seq: 1,ASP,51
referenced by entity poly seq: 1,ASP,63

CYS
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: CYS
chem comp.formula: C3 H7 N O2 S
chem comp.formula weight: 121.158
chem comp.mon nstd flag: y
chem comp.name: CYSTEINE
chem comp.type: L-peptide linking
link to chem comp: CYS
referenced by entity poly seq: 1,CYS,60

GLN
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: GLN
chem comp.formula: C5 H10 N2 O3
chem comp.formula weight: 146.144
chem comp.mon nstd flag: y
chem comp.name: GLUTAMINE
chem comp.type: L-peptide linking
link to chem comp: GLN
referenced by entity poly seq: 1,GLN,55
referenced by entity poly seq: 1,GLN,1
referenced by entity poly seq: 1,GLN,7
referenced by entity poly seq: 1,GLN,27
referenced by entity poly seq: 1,GLN,42
referenced by entity poly seq: 1,GLN,54

GLU
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: GLU
chem comp.formula: C5 H9 N O4
chem comp.formula weight: 147.129
chem comp.mon nstd flag: y
chem comp.name: GLUTAMIC ACID
chem comp.type: L-peptide linking
link to chem comp: GLU
referenced by entity poly seq: 1,GLU,78
referenced by entity poly seq: 1,GLU,6
referenced by entity poly seq: 1,GLU,8
referenced by entity poly seq: 1,GLU,35
referenced by entity poly seq: 1,GLU,52

GLY
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: GLY
chem comp.formula: C2 H5 N O2
chem comp.formula weight: 75.067
chem comp.mon nstd flag: y
chem comp.name: GLYCINE
chem comp.type: peptide linking
link to chem comp: GLY
referenced by entity poly seq: 1,GLY,95
referenced by pdbx unobs or zero occ residues: http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/3
referenced by entity poly seq: 1,GLY,25
referenced by entity poly seq: 1,GLY,41
referenced by entity poly seq: 1,GLY,66
referenced by entity poly seq: 1,GLY,70

HIS
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: HIS
chem comp.formula: C6 H10 N3 O2 1
chem comp.formula weight: 156.162
chem comp.mon nstd flag: y
chem comp.name: HISTIDINE
chem comp.type: L-peptide linking
link to chem comp: HIS
referenced by entity poly seq: 1,HIS,79
referenced by entity poly seq: 1,HIS,56

HOH
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: HOH
chem comp.formula: H2 O
chem comp.formula weight: 18.015
chem comp.name: WATER
chem comp.type: non-polymer
link to chem comp: HOH

ILE
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: ILE
chem comp.formula: C6 H13 N O2
chem comp.formula weight: 131.173
chem comp.mon nstd flag: y
chem comp.name: ISOLEUCINE
chem comp.type: L-peptide linking
link to chem comp: ILE
referenced by entity poly seq: 1,ILE,86
referenced by entity poly seq: 1,ILE,2
referenced by entity poly seq: 1,ILE,44
referenced by entity poly seq: 1,ILE,57
referenced by entity poly seq: 1,ILE,82

LEU
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: LEU
chem comp.formula: C6 H13 N O2
chem comp.formula weight: 131.173
chem comp.mon nstd flag: y
chem comp.name: LEUCINE
chem comp.type: L-peptide linking
link to chem comp: LEU
referenced by entity poly seq: 1,LEU,90
referenced by entity poly seq: 1,LEU,10
referenced by entity poly seq: 1,LEU,16
referenced by entity poly seq: 1,LEU,17
referenced by entity poly seq: 1,LEU,18
referenced by entity poly seq: 1,LEU,20
referenced by entity poly seq: 1,LEU,21
referenced by entity poly seq: 1,LEU,37
referenced by entity poly seq: 1,LEU,40
referenced by entity poly seq: 1,LEU,49
referenced by entity poly seq: 1,LEU,64
referenced by entity poly seq: 1,LEU,65
referenced by entity poly seq: 1,LEU,68

LYS
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: LYS
chem comp.formula: C6 H15 N2 O2 1
chem comp.formula weight: 147.195
chem comp.mon nstd flag: y
chem comp.name: LYSINE
chem comp.type: L-peptide linking
link to chem comp: LYS
referenced by entity poly seq: 1,LYS,81
referenced by entity poly seq: 1,LYS,14
referenced by entity poly seq: 1,LYS,19
referenced by entity poly seq: 1,LYS,22
referenced by entity poly seq: 1,LYS,28
referenced by entity poly seq: 1,LYS,34
referenced by entity poly seq: 1,LYS,47
referenced by entity poly seq: 1,LYS,53
referenced by entity poly seq: 1,LYS,77

MET
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: MET
chem comp.formula: C5 H11 N O2 S
chem comp.formula weight: 149.211
chem comp.mon nstd flag: y
chem comp.name: METHIONINE
chem comp.type: L-peptide linking
link to chem comp: MET
referenced by entity poly seq: 1,MET,85
referenced by entity poly seq: 1,MET,33
referenced by entity poly seq: 1,MET,45

PHE
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: PHE
chem comp.formula: C9 H11 N O2
chem comp.formula weight: 165.189
chem comp.mon nstd flag: y
chem comp.name: PHENYLALANINE
chem comp.type: L-peptide linking
link to chem comp: PHE
referenced by entity poly seq: 1,PHE,74
referenced by pdbx unobs or zero occ residues: http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/1
referenced by entity poly seq: 1,PHE,38
referenced by entity poly seq: 1,PHE,69

PRO
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: PRO
chem comp.formula: C5 H9 N O2
chem comp.formula weight: 115.13
chem comp.mon nstd flag: y
chem comp.name: PROLINE
chem comp.type: L-peptide linking
link to chem comp: PRO
referenced by entity poly seq: 1,PRO,72
referenced by entity poly seq: 1,PRO,3
referenced by entity poly seq: 1,PRO,13
referenced by entity poly seq: 1,PRO,15

SER
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: SER
chem comp.formula: C3 H7 N O3
chem comp.formula weight: 105.093
chem comp.mon nstd flag: y
chem comp.name: SERINE
chem comp.type: L-peptide linking
link to chem comp: SER
referenced by entity poly seq: 1,SER,96
referenced by pdbx unobs or zero occ residues: http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/4
referenced by entity poly seq: 1,SER,5
referenced by entity poly seq: 1,SER,23
referenced by entity poly seq: 1,SER,61
referenced by entity poly seq: 1,SER,73
referenced by entity poly seq: 1,SER,75

THR
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: THR
chem comp.formula: C4 H9 N O3
chem comp.formula weight: 119.119
chem comp.mon nstd flag: y
chem comp.name: THREONINE
chem comp.type: L-peptide linking
link to chem comp: THR
referenced by entity poly seq: 1,THR,84
referenced by entity poly seq: 1,THR,9
referenced by entity poly seq: 1,THR,30
referenced by entity poly seq: 1,THR,32
referenced by entity poly seq: 1,THR,46

TYR
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: TYR
chem comp.formula: C9 H11 N O3
chem comp.formula weight: 181.189
chem comp.mon nstd flag: y
chem comp.name: TYROSINE
chem comp.type: L-peptide linking
link to chem comp: TYR
referenced by entity poly seq: 1,TYR,87
referenced by entity poly seq: 1,TYR,31
referenced by entity poly seq: 1,TYR,39
referenced by entity poly seq: 1,TYR,43
referenced by entity poly seq: 1,TYR,50
referenced by entity poly seq: 1,TYR,59
referenced by entity poly seq: 1,TYR,83

VAL
type: chem comp
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
chem comp.id: VAL
chem comp.formula: C5 H11 N O2
chem comp.formula weight: 117.146
chem comp.mon nstd flag: y
chem comp.name: VALINE
chem comp.type: L-peptide linking
link to chem comp: VAL
referenced by entity poly seq: 1,VAL,93
referenced by entity poly seq: 1,VAL,11
referenced by entity poly seq: 1,VAL,24
referenced by entity poly seq: 1,VAL,36
referenced by entity poly seq: 1,VAL,58
referenced by entity poly seq: 1,VAL,71
referenced by entity poly seq: 1,VAL,76
referenced by entity poly seq: 1,VAL,91
referenced by entity poly seq: 1,VAL,92

primary
type: citation
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
citation.id: primary
citation.country: US
citation.journal abbrev: J.Med.Chem.
citation.journal id ASTM: JMCMAR
citation.journal id CSD: 0151
citation.journal id ISSN: 0022-2623
citation.journal volume: 56
citation.page first: 4053
citation.page last: 4070
citation.pdbx database id DOI: 10.1021/jm400293z
citation.pdbx database id pub med: 23597064
citation.title: Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
citation.year: 2013
link to doi: doi:10.1021/jm400293z
link to pubmed: pubmed:23597064
references: pubmed:23597064
referenced by citation author: primary,Olson, S.H.,30
referenced by citation author: primary,Gonzalez-Lopez de Turiso, F.,1
referenced by citation author: primary,Sun, D.,2
referenced by citation author: primary,Rew, Y.,3
referenced by citation author: primary,Bartberger, M.D.,4
referenced by citation author: primary,Beck, H.P.,5
referenced by citation author: primary,Canon, J.,6
referenced by citation author: primary,Chen, A.,7
referenced by citation author: primary,Chow, D.,8
referenced by citation author: primary,Correll, T.L.,9
referenced by citation author: primary,Huang, X.,10
referenced by citation author: primary,Julian, L.D.,11
referenced by citation author: primary,Kayser, F.,12
referenced by citation author: primary,Lo, M.C.,13
referenced by citation author: primary,Long, A.M.,14
referenced by citation author: primary,McMinn, D.,15
referenced by citation author: primary,Oliner, J.D.,16
referenced by citation author: primary,Osgood, T.,17
referenced by citation author: primary,Powers, J.P.,18
referenced by citation author: primary,Saiki, A.Y.,19
referenced by citation author: primary,Schneider, S.,20
referenced by citation author: primary,Shaffer, P.,21
referenced by citation author: primary,Xiao, S.H.,22
referenced by citation author: primary,Yakowec, P.,23
referenced by citation author: primary,Yan, X.,24
referenced by citation author: primary,Ye, Q.,25
referenced by citation author: primary,Yu, D.,26
referenced by citation author: primary,Zhao, X.,27
referenced by citation author: primary,Zhou, J.,28
referenced by citation author: primary,Medina, J.C.,29

primary,Gonzalez-Lopez de Turiso, F.,1
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Gonzalez-Lopez de Turiso, F.
citation author.ordinal: 1

primary,Sun, D.,2
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Sun, D.
citation author.ordinal: 2

primary,Rew, Y.,3
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Rew, Y.
citation author.ordinal: 3

primary,Bartberger, M.D.,4
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Bartberger, M.D.
citation author.ordinal: 4

primary,Beck, H.P.,5
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Beck, H.P.
citation author.ordinal: 5

primary,Canon, J.,6
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Canon, J.
citation author.ordinal: 6

primary,Chen, A.,7
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Chen, A.
citation author.ordinal: 7

primary,Chow, D.,8
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Chow, D.
citation author.ordinal: 8

primary,Correll, T.L.,9
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Correll, T.L.
citation author.ordinal: 9

primary,Huang, X.,10
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Huang, X.
citation author.ordinal: 10

primary,Julian, L.D.,11
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Julian, L.D.
citation author.ordinal: 11

primary,Kayser, F.,12
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Kayser, F.
citation author.ordinal: 12

primary,Lo, M.C.,13
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Lo, M.C.
citation author.ordinal: 13

primary,Long, A.M.,14
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Long, A.M.
citation author.ordinal: 14

primary,McMinn, D.,15
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: McMinn, D.
citation author.ordinal: 15

primary,Oliner, J.D.,16
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Oliner, J.D.
citation author.ordinal: 16

primary,Osgood, T.,17
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Osgood, T.
citation author.ordinal: 17

primary,Powers, J.P.,18
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Powers, J.P.
citation author.ordinal: 18

primary,Saiki, A.Y.,19
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Saiki, A.Y.
citation author.ordinal: 19

primary,Schneider, S.,20
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Schneider, S.
citation author.ordinal: 20

primary,Shaffer, P.,21
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Shaffer, P.
citation author.ordinal: 21

primary,Xiao, S.H.,22
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Xiao, S.H.
citation author.ordinal: 22

primary,Yakowec, P.,23
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Yakowec, P.
citation author.ordinal: 23

primary,Yan, X.,24
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Yan, X.
citation author.ordinal: 24

primary,Ye, Q.,25
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Ye, Q.
citation author.ordinal: 25

primary,Yu, D.,26
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Yu, D.
citation author.ordinal: 26

primary,Zhao, X.,27
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Zhao, X.
citation author.ordinal: 27

primary,Zhou, J.,28
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Zhou, J.
citation author.ordinal: 28

primary,Medina, J.C.,29
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Medina, J.C.
citation author.ordinal: 29

primary,Olson, S.H.,30
type: citation author
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to citation: primary
citation author.citation id: primary
citation author.name: Olson, S.H.
citation author.ordinal: 30

4JVE,PDB
type: database 2
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
database 2.database code: 4JVE
database 2.database id: PDB

RCSB078552,RCSB
type: database 2
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
database 2.database code: RCSB078552
database 2.database id: RCSB

D 1000078552,WWPDB
type: database 2
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
database 2.database code: D_1000078552
database 2.database id: WWPDB

4JVE
type: database PDB matrix
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
database PDB matrix.entry id: 4JVE
database PDB matrix.origx11: 1
database PDB matrix.origx12: 0
database PDB matrix.origx13: 0
database PDB matrix.origx21: 0
database PDB matrix.origx22: 1
database PDB matrix.origx23: 0
database PDB matrix.origx31: 0
database PDB matrix.origx32: 0
database PDB matrix.origx33: 1
database PDB matrix.origx vector1: 0
database PDB matrix.origx vector2: 0
database PDB matrix.origx vector3: 0

http://rdf.wwpdb.org/pdb/4JVE/diffrn/1
type: diffrn
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to exptl crystal: http://rdf.wwpdb.org/pdb/4JVE/exptl_crystal/1
diffrn.id: 1
diffrn.ambient temp: 100
diffrn.crystal id: 1
referenced by diffrn detector: http://rdf.wwpdb.org/pdb/4JVE/diffrn_detector/1
referenced by diffrn radiation: http://rdf.wwpdb.org/pdb/4JVE/diffrn_radiation/1
referenced by diffrn source: http://rdf.wwpdb.org/pdb/4JVE/diffrn_source/1

http://rdf.wwpdb.org/pdb/4JVE/exptl_crystal/1
referenced by diffrn: http://rdf.wwpdb.org/pdb/4JVE/diffrn/1
type: exptl crystal
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
exptl crystal.id: 1
exptl crystal.density matthews: 2.36
exptl crystal.density percent sol: 47.92
referenced by exptl crystal grow: http://rdf.wwpdb.org/pdb/4JVE/exptl_crystal_grow/1

http://rdf.wwpdb.org/pdb/4JVE/diffrn_detector/1
type: diffrn detector
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to diffrn: http://rdf.wwpdb.org/pdb/4JVE/diffrn/1
diffrn detector.diffrn id: 1
diffrn detector.detector: CCD
diffrn detector.type: MARMOSAIC 225 mm CCD

http://rdf.wwpdb.org/pdb/4JVE/diffrn_radiation/1
type: diffrn radiation
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to diffrn: http://rdf.wwpdb.org/pdb/4JVE/diffrn/1
diffrn radiation.diffrn id: 1
diffrn radiation.monochromator: Diamond(111)
diffrn radiation.pdbx diffrn protocol: SINGLE WAVELENGTH
diffrn radiation.pdbx monochromatic or laue m l: M
diffrn radiation.pdbx scattering type: x-ray
diffrn radiation.wavelength id: 1

http://rdf.wwpdb.org/pdb/4JVE/diffrn_radiation_wavelength/1
type: diffrn radiation wavelength
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
diffrn radiation wavelength.id: 1
diffrn radiation wavelength.wt: 1

http://rdf.wwpdb.org/pdb/4JVE/diffrn_source/1
type: diffrn source
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to diffrn: http://rdf.wwpdb.org/pdb/4JVE/diffrn/1
diffrn source.diffrn id: 1
diffrn source.pdbx synchrotron beamline: 21-ID-F
diffrn source.pdbx synchrotron site: APS
diffrn source.source: SYNCHROTRON
diffrn source.type: APS BEAMLINE 21-ID-F

http://rdf.wwpdb.org/pdb/4JVE/entity/1
type: entity
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
entity.id: 1
entity.formula weight: 11156.052
entity.pdbx description: E3 ubiquitin-protein ligase Mdm2
entity.pdbx ec: 6.3.2.-
entity.pdbx fragment: UNP residues 18-111
entity.pdbx number of molecules: 1
entity.src method: man
entity.type: polymer
link to enzyme: enzyme:6.3.2.-
referenced by entity name com: http://rdf.wwpdb.org/pdb/4JVE/entity_name_com/1
referenced by entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
referenced by struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
referenced by struct ref: http://rdf.wwpdb.org/pdb/4JVE/struct_ref/1
referenced by entity src gen: 1,1

ec-code:6.3.2.-

http://rdf.wwpdb.org/pdb/4JVE/entity/2
type: entity
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
entity.id: 2
entity.formula weight: 528.399
entity.pdbx description: (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
entity.pdbx number of molecules: 1
entity.src method: syn
entity.type: non-polymer
referenced by struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/B
referenced by pdbx entity nonpoly: http://rdf.wwpdb.org/pdb/4JVE/pdbx_entity_nonpoly/2

http://rdf.wwpdb.org/pdb/4JVE/entity/3
type: entity
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
entity.id: 3
entity.formula weight: 18.015
entity.pdbx description: water
entity.pdbx number of molecules: 40
entity.src method: nat
entity.type: water
referenced by struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/C
referenced by pdbx entity nonpoly: http://rdf.wwpdb.org/pdb/4JVE/pdbx_entity_nonpoly/3

http://rdf.wwpdb.org/pdb/4JVE/entity_name_com/1
type: entity name com
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/1
entity name com.entity id: 1
entity name com.name: Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2

http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
type: entity poly
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/1
entity poly.entity id: 1
entity poly.nstd linkage: no
entity poly.nstd monomer: no
entity poly.pdbx seq one letter code: QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHR KIYTMIYRNLVVVNGS
entity poly.pdbx seq one letter code can: QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHR KIYTMIYRNLVVVNGS
entity poly.pdbx strand id: A
entity poly.type: polypeptide(L)
referenced by entity poly seq: 1,SER,96
referenced by entity poly seq: 1,GLN,1
referenced by entity poly seq: 1,ILE,2
referenced by entity poly seq: 1,PRO,3
referenced by entity poly seq: 1,ALA,4
referenced by entity poly seq: 1,SER,5
referenced by entity poly seq: 1,GLU,6
referenced by entity poly seq: 1,GLN,7
referenced by entity poly seq: 1,GLU,8
referenced by entity poly seq: 1,THR,9
referenced by entity poly seq: 1,LEU,10
referenced by entity poly seq: 1,VAL,11
referenced by entity poly seq: 1,ARG,12
referenced by entity poly seq: 1,PRO,13
referenced by entity poly seq: 1,LYS,14
referenced by entity poly seq: 1,PRO,15
referenced by entity poly seq: 1,LEU,16
referenced by entity poly seq: 1,LEU,17
referenced by entity poly seq: 1,LEU,18
referenced by entity poly seq: 1,LYS,19
referenced by entity poly seq: 1,LEU,20
referenced by entity poly seq: 1,LEU,21
referenced by entity poly seq: 1,LYS,22
referenced by entity poly seq: 1,SER,23
referenced by entity poly seq: 1,VAL,24
referenced by entity poly seq: 1,GLY,25
referenced by entity poly seq: 1,ALA,26
referenced by entity poly seq: 1,GLN,27
referenced by entity poly seq: 1,LYS,28
referenced by entity poly seq: 1,ASP,29
referenced by entity poly seq: 1,THR,30
referenced by entity poly seq: 1,TYR,31
referenced by entity poly seq: 1,THR,32
referenced by entity poly seq: 1,MET,33
referenced by entity poly seq: 1,LYS,34
referenced by entity poly seq: 1,GLU,35
referenced by entity poly seq: 1,VAL,36
referenced by entity poly seq: 1,LEU,37
referenced by entity poly seq: 1,PHE,38
referenced by entity poly seq: 1,TYR,39
referenced by entity poly seq: 1,LEU,40
referenced by entity poly seq: 1,GLY,41
referenced by entity poly seq: 1,GLN,42
referenced by entity poly seq: 1,TYR,43
referenced by entity poly seq: 1,ILE,44
referenced by entity poly seq: 1,MET,45
referenced by entity poly seq: 1,THR,46
referenced by entity poly seq: 1,LYS,47
referenced by entity poly seq: 1,ARG,48
referenced by entity poly seq: 1,LEU,49
referenced by entity poly seq: 1,TYR,50
referenced by entity poly seq: 1,ASP,51
referenced by entity poly seq: 1,GLU,52
referenced by entity poly seq: 1,LYS,53
referenced by entity poly seq: 1,GLN,54
referenced by entity poly seq: 1,GLN,55
referenced by entity poly seq: 1,HIS,56
referenced by entity poly seq: 1,ILE,57
referenced by entity poly seq: 1,VAL,58
referenced by entity poly seq: 1,TYR,59
referenced by entity poly seq: 1,CYS,60
referenced by entity poly seq: 1,SER,61
referenced by entity poly seq: 1,ASN,62
referenced by entity poly seq: 1,ASP,63
referenced by entity poly seq: 1,LEU,64
referenced by entity poly seq: 1,LEU,65
referenced by entity poly seq: 1,GLY,66
referenced by entity poly seq: 1,ASP,67
referenced by entity poly seq: 1,LEU,68
referenced by entity poly seq: 1,PHE,69

1,GLN,1
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLN
entity poly seq.num: 1
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLN,1

1,ILE,2
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ILE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ILE
entity poly seq.num: 2
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ILE,2

1,PRO,3
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PRO
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: PRO
entity poly seq.num: 3
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,PRO,3

1,ALA,4
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ALA
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ALA
entity poly seq.num: 4
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ALA,4

1,SER,5
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: SER
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: SER
entity poly seq.num: 5
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,SER,5

1,GLU,6
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLU
entity poly seq.num: 6
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLU,6

1,GLN,7
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLN
entity poly seq.num: 7
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLN,7

1,GLU,8
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLU
entity poly seq.num: 8
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLU,8

1,THR,9
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: THR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: THR
entity poly seq.num: 9
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,THR,9

1,LEU,10
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 10
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,10

1,VAL,11
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 11
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,11

1,ARG,12
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ARG
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ARG
entity poly seq.num: 12
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ARG,12

1,PRO,13
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PRO
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: PRO
entity poly seq.num: 13
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,PRO,13

1,LYS,14
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 14
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,14

1,PRO,15
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PRO
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: PRO
entity poly seq.num: 15
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,PRO,15

1,LEU,16
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 16
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,16

1,LEU,17
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 17
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,17

1,LEU,18
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 18
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,18

1,LYS,19
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 19
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,19

1,LEU,20
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 20
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,20

1,LEU,21
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 21
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,21

1,LYS,22
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 22
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,22

1,SER,23
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: SER
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: SER
entity poly seq.num: 23
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,SER,23

1,VAL,24
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 24
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,24

1,GLY,25
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLY
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLY
entity poly seq.num: 25
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLY,25

1,ALA,26
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ALA
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ALA
entity poly seq.num: 26
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ALA,26

1,GLN,27
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLN
entity poly seq.num: 27
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLN,27

1,LYS,28
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 28
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,28

1,ASP,29
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASP
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ASP
entity poly seq.num: 29
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ASP,29

1,THR,30
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: THR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: THR
entity poly seq.num: 30
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,THR,30

1,TYR,31
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: TYR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: TYR
entity poly seq.num: 31
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,TYR,31

1,THR,32
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: THR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: THR
entity poly seq.num: 32
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,THR,32

1,MET,33
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: MET
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: MET
entity poly seq.num: 33
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,MET,33

1,LYS,34
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 34
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,34

1,GLU,35
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLU
entity poly seq.num: 35
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLU,35

1,VAL,36
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 36
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,36

1,LEU,37
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 37
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,37

1,PHE,38
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PHE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: PHE
entity poly seq.num: 38
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,PHE,38

1,TYR,39
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: TYR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: TYR
entity poly seq.num: 39
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,TYR,39

1,LEU,40
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 40
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,40

1,GLY,41
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLY
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLY
entity poly seq.num: 41
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLY,41

1,GLN,42
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLN
entity poly seq.num: 42
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLN,42

1,TYR,43
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: TYR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: TYR
entity poly seq.num: 43
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,TYR,43

1,ILE,44
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ILE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ILE
entity poly seq.num: 44
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ILE,44

1,MET,45
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: MET
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: MET
entity poly seq.num: 45
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,MET,45

1,THR,46
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: THR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: THR
entity poly seq.num: 46
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,THR,46

1,LYS,47
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 47
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,47

1,ARG,48
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ARG
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ARG
entity poly seq.num: 48
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ARG,48

1,LEU,49
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 49
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,49

1,TYR,50
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: TYR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: TYR
entity poly seq.num: 50
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,TYR,50

1,ASP,51
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASP
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ASP
entity poly seq.num: 51
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ASP,51

1,GLU,52
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLU
entity poly seq.num: 52
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLU,52

1,LYS,53
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 53
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,53

1,GLN,54
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLN
entity poly seq.num: 54
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLN,54

1,GLN,55
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLN
entity poly seq.num: 55
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLN,55

1,HIS,56
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: HIS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: HIS
entity poly seq.num: 56
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,HIS,56

1,ILE,57
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ILE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ILE
entity poly seq.num: 57
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ILE,57

1,VAL,58
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 58
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,58

1,TYR,59
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: TYR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: TYR
entity poly seq.num: 59
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,TYR,59

1,CYS,60
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: CYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: CYS
entity poly seq.num: 60
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,CYS,60

1,SER,61
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: SER
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: SER
entity poly seq.num: 61
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,SER,61

1,ASN,62
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ASN
entity poly seq.num: 62
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ASN,62

1,ASP,63
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASP
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ASP
entity poly seq.num: 63
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ASP,63

1,LEU,64
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 64
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,64

1,LEU,65
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 65
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,65

1,GLY,66
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLY
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLY
entity poly seq.num: 66
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLY,66

1,ASP,67
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASP
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ASP
entity poly seq.num: 67
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ASP,67

1,LEU,68
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 68
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,68

1,PHE,69
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PHE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: PHE
entity poly seq.num: 69
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,PHE,69

1,GLY,70
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLY
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLY
entity poly seq.num: 70
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLY,70

1,VAL,71
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 71
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,71

1,PRO,72
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PRO
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: PRO
entity poly seq.num: 72
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,PRO,72

1,SER,73
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: SER
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: SER
entity poly seq.num: 73
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,SER,73

1,PHE,74
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PHE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: PHE
entity poly seq.num: 74
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,PHE,74

1,SER,75
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: SER
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: SER
entity poly seq.num: 75
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,SER,75

1,VAL,76
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 76
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,76

1,LYS,77
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 77
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,77

1,GLU,78
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLU
entity poly seq.num: 78
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLU,78

1,HIS,79
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: HIS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: HIS
entity poly seq.num: 79
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,HIS,79

1,ARG,80
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ARG
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ARG
entity poly seq.num: 80
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ARG,80

1,LYS,81
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LYS
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LYS
entity poly seq.num: 81
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LYS,81

1,ILE,82
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ILE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ILE
entity poly seq.num: 82
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ILE,82

1,TYR,83
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: TYR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: TYR
entity poly seq.num: 83
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,TYR,83

1,THR,84
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: THR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: THR
entity poly seq.num: 84
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,THR,84

1,MET,85
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: MET
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: MET
entity poly seq.num: 85
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,MET,85

1,ILE,86
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ILE
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ILE
entity poly seq.num: 86
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ILE,86

1,TYR,87
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: TYR
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: TYR
entity poly seq.num: 87
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,TYR,87

1,ARG,88
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ARG
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ARG
entity poly seq.num: 88
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ARG,88

1,ASN,89
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ASN
entity poly seq.num: 89
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ASN,89

1,LEU,90
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: LEU
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: LEU
entity poly seq.num: 90
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,LEU,90

1,VAL,91
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 91
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,91

1,VAL,92
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 92
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,92

1,VAL,93
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: VAL
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: VAL
entity poly seq.num: 93
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,VAL,93

1,ASN,94
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASN
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: ASN
entity poly seq.num: 94
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,ASN,94

1,GLY,95
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLY
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: GLY
entity poly seq.num: 95
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,GLY,95

1,SER,96
type: entity poly seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: SER
reference to entity poly: http://rdf.wwpdb.org/pdb/4JVE/entity_poly/1
entity poly seq.entity id: 1
entity poly seq.mon id: SER
entity poly seq.num: 96
entity poly seq.hetero: n
referenced by pdbx poly seq scheme: A,1,SER,96

1,1
type: entity src gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/1
entity src gen.entity id: 1
entity src gen.pdbx src id: 1
entity src gen.gene src common name: human
entity src gen.pdbx alt source flag: sample
entity src gen.pdbx gene src gene: MDM2
entity src gen.pdbx gene src ncbi taxonomy id: 9606
entity src gen.pdbx gene src scientific name: Homo sapiens
entity src gen.pdbx host org ncbi taxonomy id: 562
entity src gen.pdbx host org scientific name: Escherichia coli
link to taxonomy source: taxonomy:9606
link to taxonomy host: taxonomy:562

taxonomy:9606

taxonomy:562

4JVE,X-RAY DIFFRACTION
type: exptl
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
exptl.entry id: 4JVE
exptl.method: X-RAY DIFFRACTION
exptl.crystals number: 1

http://rdf.wwpdb.org/pdb/4JVE/exptl_crystal_grow/1
type: exptl crystal grow
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to exptl crystal: http://rdf.wwpdb.org/pdb/4JVE/exptl_crystal/1
exptl crystal grow.crystal id: 1
exptl crystal grow.method: VAPOR DIFFUSION, HANGING DROP
exptl crystal grow.p h: 9
exptl crystal grow.pdbx details: 100 mM Bicine, pH 9.0, 1.6 M ammonium sulfate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
exptl crystal grow.temp: 277

Structure model,1,1
type: pdbx audit revision details
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to pdbx audit revision history: Structure model,1
pdbx audit revision details.data content type: Structure model
pdbx audit revision details.ordinal: 1
pdbx audit revision details.revision ordinal: 1
pdbx audit revision details.provider: repository
pdbx audit revision details.type: Initial release

Structure model,1
referenced by pdbx audit revision details: Structure model,1,1
type: pdbx audit revision history
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx audit revision history.data content type: Structure model
pdbx audit revision history.ordinal: 1
pdbx audit revision history.major revision: 1
pdbx audit revision history.minor revision: 0
pdbx audit revision history.revision date: 2013-05-01

Structure model,1,2
type: pdbx audit revision group
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to pdbx audit revision history: Structure model,2
pdbx audit revision group.data content type: Structure model
pdbx audit revision group.ordinal: 1
pdbx audit revision group.revision ordinal: 2
pdbx audit revision group.group: Database references

Structure model,2
referenced by pdbx audit revision group: Structure model,1,2
type: pdbx audit revision history
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx audit revision history.data content type: Structure model
pdbx audit revision history.ordinal: 2
pdbx audit revision history.major revision: 1
pdbx audit revision history.minor revision: 1
pdbx audit revision history.revision date: 2013-06-05

unspecified,4JV7,PDB
type: pdbx database related
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx database related.content type: unspecified
pdbx database related.db id: 4JV7
pdbx database related.db name: PDB

unspecified,4JV9,PDB
type: pdbx database related
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx database related.content type: unspecified
pdbx database related.db id: 4JV9
pdbx database related.db name: PDB

unspecified,4JVR,PDB
type: pdbx database related
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx database related.content type: unspecified
pdbx database related.db id: 4JVR
pdbx database related.db name: PDB

unspecified,4JWR,PDB
type: pdbx database related
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx database related.content type: unspecified
pdbx database related.db id: 4JWR
pdbx database related.db name: PDB

4JVE
type: pdbx database status
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
pdbx database status.entry id: 4JVE
pdbx database status.deposit site: RCSB
pdbx database status.pdb format compatible: Y
pdbx database status.process site: RCSB
pdbx database status.recvd initial deposition date: 2013-03-25
pdbx database status.status code: REL
pdbx database status.status code sf: REL

http://rdf.wwpdb.org/pdb/4JVE/pdbx_entity_nonpoly/2
type: pdbx entity nonpoly
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/2
pdbx entity nonpoly.entity id: 2
pdbx entity nonpoly.comp id: 1MQ
pdbx entity nonpoly.name: (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid

http://rdf.wwpdb.org/pdb/4JVE/pdbx_entity_nonpoly/3
type: pdbx entity nonpoly
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/3
pdbx entity nonpoly.entity id: 3
pdbx entity nonpoly.comp id: HOH
pdbx entity nonpoly.name: water

B,1
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: B
pdbx nonpoly scheme.ndb seq num: 1
pdbx nonpoly scheme.auth mon id: INH
pdbx nonpoly scheme.auth seq num: 1
pdbx nonpoly scheme.entity id: 2
pdbx nonpoly scheme.mon id: 1MQ
pdbx nonpoly scheme.pdb mon id: 1MQ
pdbx nonpoly scheme.pdb seq num: 201
pdbx nonpoly scheme.pdb strand id: A

C,1
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 1
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 3
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 301
pdbx nonpoly scheme.pdb strand id: A

C,2
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 2
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 10
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 302
pdbx nonpoly scheme.pdb strand id: A

C,3
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 3
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 14
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 303
pdbx nonpoly scheme.pdb strand id: A

C,4
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 4
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 16
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 304
pdbx nonpoly scheme.pdb strand id: A

C,5
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 5
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 21
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 305
pdbx nonpoly scheme.pdb strand id: A

C,6
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 6
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 25
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 306
pdbx nonpoly scheme.pdb strand id: A

C,7
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 7
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 26
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 307
pdbx nonpoly scheme.pdb strand id: A

C,8
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 8
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 30
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 308
pdbx nonpoly scheme.pdb strand id: A

C,9
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 9
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 34
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 309
pdbx nonpoly scheme.pdb strand id: A

C,10
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 10
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 38
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 310
pdbx nonpoly scheme.pdb strand id: A

C,11
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 11
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 40
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 311
pdbx nonpoly scheme.pdb strand id: A

C,12
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 12
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 44
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 312
pdbx nonpoly scheme.pdb strand id: A

C,13
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 13
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 46
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 313
pdbx nonpoly scheme.pdb strand id: A

C,14
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 14
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 48
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 314
pdbx nonpoly scheme.pdb strand id: A

C,15
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 15
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 52
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 315
pdbx nonpoly scheme.pdb strand id: A

C,16
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 16
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 53
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 316
pdbx nonpoly scheme.pdb strand id: A

C,17
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 17
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 57
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 317
pdbx nonpoly scheme.pdb strand id: A

C,18
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 18
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 59
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 318
pdbx nonpoly scheme.pdb strand id: A

C,19
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 19
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 60
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 319
pdbx nonpoly scheme.pdb strand id: A

C,20
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 20
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 63
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 320
pdbx nonpoly scheme.pdb strand id: A

C,21
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 21
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 64
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 321
pdbx nonpoly scheme.pdb strand id: A

C,22
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 22
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 65
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 322
pdbx nonpoly scheme.pdb strand id: A

C,23
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 23
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 66
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 323
pdbx nonpoly scheme.pdb strand id: A

C,24
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 24
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 67
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 324
pdbx nonpoly scheme.pdb strand id: A

C,25
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 25
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 68
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 325
pdbx nonpoly scheme.pdb strand id: A

C,26
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 26
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 69
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 326
pdbx nonpoly scheme.pdb strand id: A

C,27
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 27
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 74
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 327
pdbx nonpoly scheme.pdb strand id: A

C,28
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 28
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 75
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 328
pdbx nonpoly scheme.pdb strand id: A

C,29
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 29
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 76
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 329
pdbx nonpoly scheme.pdb strand id: A

C,30
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 30
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 78
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 330
pdbx nonpoly scheme.pdb strand id: A

C,31
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 31
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 79
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 331
pdbx nonpoly scheme.pdb strand id: A

C,32
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 32
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 80
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 332
pdbx nonpoly scheme.pdb strand id: A

C,33
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 33
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 85
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 333
pdbx nonpoly scheme.pdb strand id: A

C,34
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 34
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 86
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 334
pdbx nonpoly scheme.pdb strand id: A

C,35
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 35
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 88
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 335
pdbx nonpoly scheme.pdb strand id: A

C,36
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 36
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 89
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 336
pdbx nonpoly scheme.pdb strand id: A

C,37
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 37
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 90
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 337
pdbx nonpoly scheme.pdb strand id: A

C,38
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 38
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 96
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 338
pdbx nonpoly scheme.pdb strand id: A

C,39
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 39
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 97
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 339
pdbx nonpoly scheme.pdb strand id: A

C,40
type: pdbx nonpoly scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx nonpoly scheme.asym id: C
pdbx nonpoly scheme.ndb seq num: 40
pdbx nonpoly scheme.auth mon id: HOH
pdbx nonpoly scheme.auth seq num: 100
pdbx nonpoly scheme.entity id: 3
pdbx nonpoly scheme.mon id: HOH
pdbx nonpoly scheme.pdb mon id: HOH
pdbx nonpoly scheme.pdb seq num: 340
pdbx nonpoly scheme.pdb strand id: A

A,1,GLN,1
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLN,1
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLN
pdbx poly seq scheme.seq id: 1
pdbx poly seq scheme.auth mon id: GLN
pdbx poly seq scheme.auth seq num: 18
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 1
pdbx poly seq scheme.pdb mon id: GLN
pdbx poly seq scheme.pdb seq num: 18
pdbx poly seq scheme.pdb strand id: A

http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
referenced by pdbx poly seq scheme: A,1,GLN,1
referenced by pdbx poly seq scheme: A,1,ILE,2
referenced by pdbx poly seq scheme: A,1,PRO,3
referenced by pdbx poly seq scheme: A,1,ALA,4
referenced by pdbx poly seq scheme: A,1,SER,5
referenced by pdbx poly seq scheme: A,1,GLU,6
referenced by pdbx poly seq scheme: A,1,GLN,7
referenced by pdbx poly seq scheme: A,1,GLU,8
referenced by pdbx poly seq scheme: A,1,THR,9
referenced by pdbx poly seq scheme: A,1,LEU,10
referenced by pdbx poly seq scheme: A,1,VAL,11
referenced by pdbx poly seq scheme: A,1,ARG,12
referenced by pdbx poly seq scheme: A,1,PRO,13
referenced by pdbx poly seq scheme: A,1,LYS,14
referenced by pdbx poly seq scheme: A,1,PRO,15
referenced by pdbx poly seq scheme: A,1,LEU,16
referenced by pdbx poly seq scheme: A,1,LEU,17
referenced by pdbx poly seq scheme: A,1,LEU,18
referenced by pdbx poly seq scheme: A,1,LYS,19
referenced by pdbx poly seq scheme: A,1,LEU,20
referenced by pdbx poly seq scheme: A,1,LEU,21
referenced by pdbx poly seq scheme: A,1,LYS,22
referenced by pdbx poly seq scheme: A,1,SER,23
referenced by pdbx poly seq scheme: A,1,VAL,24
referenced by pdbx poly seq scheme: A,1,GLY,25
referenced by pdbx poly seq scheme: A,1,ALA,26
referenced by pdbx poly seq scheme: A,1,GLN,27
referenced by pdbx poly seq scheme: A,1,LYS,28
referenced by pdbx poly seq scheme: A,1,ASP,29
referenced by pdbx poly seq scheme: A,1,THR,30
referenced by pdbx poly seq scheme: A,1,TYR,31
referenced by pdbx poly seq scheme: A,1,THR,32
referenced by pdbx poly seq scheme: A,1,MET,33
referenced by pdbx poly seq scheme: A,1,LYS,34
referenced by pdbx poly seq scheme: A,1,GLU,35
referenced by pdbx poly seq scheme: A,1,VAL,36
referenced by pdbx poly seq scheme: A,1,LEU,37
referenced by pdbx poly seq scheme: A,1,PHE,38
referenced by pdbx poly seq scheme: A,1,TYR,39
referenced by pdbx poly seq scheme: A,1,LEU,40
referenced by pdbx poly seq scheme: A,1,GLY,41
referenced by pdbx poly seq scheme: A,1,GLN,42
referenced by pdbx poly seq scheme: A,1,TYR,43
referenced by pdbx poly seq scheme: A,1,ILE,44
referenced by pdbx poly seq scheme: A,1,MET,45
referenced by pdbx poly seq scheme: A,1,THR,46
referenced by pdbx poly seq scheme: A,1,LYS,47
referenced by pdbx poly seq scheme: A,1,ARG,48
referenced by pdbx poly seq scheme: A,1,LEU,49
referenced by pdbx poly seq scheme: A,1,TYR,50
referenced by pdbx poly seq scheme: A,1,ASP,51
referenced by pdbx poly seq scheme: A,1,GLU,52
referenced by pdbx poly seq scheme: A,1,LYS,53
referenced by pdbx poly seq scheme: A,1,GLN,54
referenced by pdbx poly seq scheme: A,1,GLN,55
referenced by pdbx poly seq scheme: A,1,HIS,56
referenced by pdbx poly seq scheme: A,1,ILE,57
referenced by pdbx poly seq scheme: A,1,VAL,58
referenced by pdbx poly seq scheme: A,1,TYR,59
referenced by pdbx poly seq scheme: A,1,CYS,60
referenced by pdbx poly seq scheme: A,1,SER,61
referenced by pdbx poly seq scheme: A,1,ASN,62
referenced by pdbx poly seq scheme: A,1,ASP,63
referenced by pdbx poly seq scheme: A,1,LEU,64
referenced by pdbx poly seq scheme: A,1,LEU,65
referenced by pdbx poly seq scheme: A,1,GLY,66
referenced by pdbx poly seq scheme: A,1,ASP,67
referenced by pdbx poly seq scheme: A,1,LEU,68
referenced by pdbx poly seq scheme: A,1,PHE,69
referenced by pdbx poly seq scheme: A,1,GLY,70
referenced by pdbx poly seq scheme: A,1,VAL,71
referenced by pdbx poly seq scheme: A,1,PRO,72
referenced by pdbx poly seq scheme: A,1,SER,73
referenced by pdbx poly seq scheme: A,1,PHE,74
referenced by pdbx poly seq scheme: A,1,SER,75
referenced by pdbx poly seq scheme: A,1,VAL,76
referenced by pdbx poly seq scheme: A,1,LYS,77
referenced by pdbx poly seq scheme: A,1,GLU,78
referenced by pdbx poly seq scheme: A,1,HIS,79
referenced by pdbx poly seq scheme: A,1,ARG,80

A,1,ILE,2
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ILE,2
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ILE
pdbx poly seq scheme.seq id: 2
pdbx poly seq scheme.auth mon id: ILE
pdbx poly seq scheme.auth seq num: 19
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 2
pdbx poly seq scheme.pdb mon id: ILE
pdbx poly seq scheme.pdb seq num: 19
pdbx poly seq scheme.pdb strand id: A

A,1,PRO,3
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,PRO,3
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: PRO
pdbx poly seq scheme.seq id: 3
pdbx poly seq scheme.auth mon id: PRO
pdbx poly seq scheme.auth seq num: 20
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 3
pdbx poly seq scheme.pdb mon id: PRO
pdbx poly seq scheme.pdb seq num: 20
pdbx poly seq scheme.pdb strand id: A

A,1,ALA,4
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ALA,4
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ALA
pdbx poly seq scheme.seq id: 4
pdbx poly seq scheme.auth mon id: ALA
pdbx poly seq scheme.auth seq num: 21
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 4
pdbx poly seq scheme.pdb mon id: ALA
pdbx poly seq scheme.pdb seq num: 21
pdbx poly seq scheme.pdb strand id: A

A,1,SER,5
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,SER,5
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: SER
pdbx poly seq scheme.seq id: 5
pdbx poly seq scheme.auth mon id: SER
pdbx poly seq scheme.auth seq num: 22
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 5
pdbx poly seq scheme.pdb mon id: SER
pdbx poly seq scheme.pdb seq num: 22
pdbx poly seq scheme.pdb strand id: A

A,1,GLU,6
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLU,6
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLU
pdbx poly seq scheme.seq id: 6
pdbx poly seq scheme.auth mon id: GLU
pdbx poly seq scheme.auth seq num: 23
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 6
pdbx poly seq scheme.pdb mon id: GLU
pdbx poly seq scheme.pdb seq num: 23
pdbx poly seq scheme.pdb strand id: A

A,1,GLN,7
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLN,7
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLN
pdbx poly seq scheme.seq id: 7
pdbx poly seq scheme.auth mon id: GLN
pdbx poly seq scheme.auth seq num: 24
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 7
pdbx poly seq scheme.pdb mon id: GLN
pdbx poly seq scheme.pdb seq num: 24
pdbx poly seq scheme.pdb strand id: A

A,1,GLU,8
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLU,8
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLU
pdbx poly seq scheme.seq id: 8
pdbx poly seq scheme.auth mon id: GLU
pdbx poly seq scheme.auth seq num: 25
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 8
pdbx poly seq scheme.pdb mon id: GLU
pdbx poly seq scheme.pdb seq num: 25
pdbx poly seq scheme.pdb strand id: A

A,1,THR,9
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,THR,9
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: THR
pdbx poly seq scheme.seq id: 9
pdbx poly seq scheme.auth mon id: THR
pdbx poly seq scheme.auth seq num: 26
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 9
pdbx poly seq scheme.pdb mon id: THR
pdbx poly seq scheme.pdb seq num: 26
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,10
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,10
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 10
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 27
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 10
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 27
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,11
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,11
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 11
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 28
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 11
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 28
pdbx poly seq scheme.pdb strand id: A

A,1,ARG,12
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ARG,12
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ARG
pdbx poly seq scheme.seq id: 12
pdbx poly seq scheme.auth mon id: ARG
pdbx poly seq scheme.auth seq num: 29
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 12
pdbx poly seq scheme.pdb mon id: ARG
pdbx poly seq scheme.pdb seq num: 29
pdbx poly seq scheme.pdb strand id: A

A,1,PRO,13
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,PRO,13
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: PRO
pdbx poly seq scheme.seq id: 13
pdbx poly seq scheme.auth mon id: PRO
pdbx poly seq scheme.auth seq num: 30
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 13
pdbx poly seq scheme.pdb mon id: PRO
pdbx poly seq scheme.pdb seq num: 30
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,14
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,14
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 14
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 31
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 14
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 31
pdbx poly seq scheme.pdb strand id: A

A,1,PRO,15
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,PRO,15
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: PRO
pdbx poly seq scheme.seq id: 15
pdbx poly seq scheme.auth mon id: PRO
pdbx poly seq scheme.auth seq num: 32
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 15
pdbx poly seq scheme.pdb mon id: PRO
pdbx poly seq scheme.pdb seq num: 32
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,16
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,16
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 16
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 33
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 16
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 33
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,17
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,17
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 17
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 34
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 17
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 34
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,18
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,18
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 18
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 35
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 18
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 35
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,19
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,19
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 19
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 36
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 19
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 36
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,20
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,20
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 20
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 37
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 20
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 37
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,21
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,21
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 21
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 38
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 21
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 38
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,22
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,22
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 22
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 39
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 22
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 39
pdbx poly seq scheme.pdb strand id: A

A,1,SER,23
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,SER,23
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: SER
pdbx poly seq scheme.seq id: 23
pdbx poly seq scheme.auth mon id: SER
pdbx poly seq scheme.auth seq num: 40
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 23
pdbx poly seq scheme.pdb mon id: SER
pdbx poly seq scheme.pdb seq num: 40
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,24
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,24
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 24
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 41
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 24
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 41
pdbx poly seq scheme.pdb strand id: A

A,1,GLY,25
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLY,25
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLY
pdbx poly seq scheme.seq id: 25
pdbx poly seq scheme.auth mon id: GLY
pdbx poly seq scheme.auth seq num: 42
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 25
pdbx poly seq scheme.pdb mon id: GLY
pdbx poly seq scheme.pdb seq num: 42
pdbx poly seq scheme.pdb strand id: A

A,1,ALA,26
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ALA,26
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ALA
pdbx poly seq scheme.seq id: 26
pdbx poly seq scheme.auth mon id: ALA
pdbx poly seq scheme.auth seq num: 43
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 26
pdbx poly seq scheme.pdb mon id: ALA
pdbx poly seq scheme.pdb seq num: 43
pdbx poly seq scheme.pdb strand id: A

A,1,GLN,27
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLN,27
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLN
pdbx poly seq scheme.seq id: 27
pdbx poly seq scheme.auth mon id: GLN
pdbx poly seq scheme.auth seq num: 44
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 27
pdbx poly seq scheme.pdb mon id: GLN
pdbx poly seq scheme.pdb seq num: 44
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,28
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,28
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 28
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 45
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 28
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 45
pdbx poly seq scheme.pdb strand id: A

A,1,ASP,29
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ASP,29
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ASP
pdbx poly seq scheme.seq id: 29
pdbx poly seq scheme.auth mon id: ASP
pdbx poly seq scheme.auth seq num: 46
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 29
pdbx poly seq scheme.pdb mon id: ASP
pdbx poly seq scheme.pdb seq num: 46
pdbx poly seq scheme.pdb strand id: A

A,1,THR,30
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,THR,30
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: THR
pdbx poly seq scheme.seq id: 30
pdbx poly seq scheme.auth mon id: THR
pdbx poly seq scheme.auth seq num: 47
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 30
pdbx poly seq scheme.pdb mon id: THR
pdbx poly seq scheme.pdb seq num: 47
pdbx poly seq scheme.pdb strand id: A

A,1,TYR,31
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,TYR,31
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: TYR
pdbx poly seq scheme.seq id: 31
pdbx poly seq scheme.auth mon id: TYR
pdbx poly seq scheme.auth seq num: 48
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 31
pdbx poly seq scheme.pdb mon id: TYR
pdbx poly seq scheme.pdb seq num: 48
pdbx poly seq scheme.pdb strand id: A

A,1,THR,32
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,THR,32
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: THR
pdbx poly seq scheme.seq id: 32
pdbx poly seq scheme.auth mon id: THR
pdbx poly seq scheme.auth seq num: 49
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 32
pdbx poly seq scheme.pdb mon id: THR
pdbx poly seq scheme.pdb seq num: 49
pdbx poly seq scheme.pdb strand id: A

A,1,MET,33
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,MET,33
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: MET
pdbx poly seq scheme.seq id: 33
pdbx poly seq scheme.auth mon id: MET
pdbx poly seq scheme.auth seq num: 50
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 33
pdbx poly seq scheme.pdb mon id: MET
pdbx poly seq scheme.pdb seq num: 50
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,34
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,34
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 34
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 51
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 34
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 51
pdbx poly seq scheme.pdb strand id: A

A,1,GLU,35
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLU,35
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLU
pdbx poly seq scheme.seq id: 35
pdbx poly seq scheme.auth mon id: GLU
pdbx poly seq scheme.auth seq num: 52
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 35
pdbx poly seq scheme.pdb mon id: GLU
pdbx poly seq scheme.pdb seq num: 52
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,36
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,36
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 36
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 53
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 36
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 53
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,37
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,37
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 37
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 54
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 37
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 54
pdbx poly seq scheme.pdb strand id: A

A,1,PHE,38
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,PHE,38
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: PHE
pdbx poly seq scheme.seq id: 38
pdbx poly seq scheme.auth mon id: PHE
pdbx poly seq scheme.auth seq num: 55
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 38
pdbx poly seq scheme.pdb mon id: PHE
pdbx poly seq scheme.pdb seq num: 55
pdbx poly seq scheme.pdb strand id: A

A,1,TYR,39
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,TYR,39
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: TYR
pdbx poly seq scheme.seq id: 39
pdbx poly seq scheme.auth mon id: TYR
pdbx poly seq scheme.auth seq num: 56
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 39
pdbx poly seq scheme.pdb mon id: TYR
pdbx poly seq scheme.pdb seq num: 56
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,40
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,40
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 40
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 57
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 40
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 57
pdbx poly seq scheme.pdb strand id: A

A,1,GLY,41
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLY,41
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLY
pdbx poly seq scheme.seq id: 41
pdbx poly seq scheme.auth mon id: GLY
pdbx poly seq scheme.auth seq num: 58
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 41
pdbx poly seq scheme.pdb mon id: GLY
pdbx poly seq scheme.pdb seq num: 58
pdbx poly seq scheme.pdb strand id: A

A,1,GLN,42
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLN,42
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLN
pdbx poly seq scheme.seq id: 42
pdbx poly seq scheme.auth mon id: GLN
pdbx poly seq scheme.auth seq num: 59
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 42
pdbx poly seq scheme.pdb mon id: GLN
pdbx poly seq scheme.pdb seq num: 59
pdbx poly seq scheme.pdb strand id: A

A,1,TYR,43
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,TYR,43
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: TYR
pdbx poly seq scheme.seq id: 43
pdbx poly seq scheme.auth mon id: TYR
pdbx poly seq scheme.auth seq num: 60
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 43
pdbx poly seq scheme.pdb mon id: TYR
pdbx poly seq scheme.pdb seq num: 60
pdbx poly seq scheme.pdb strand id: A

A,1,ILE,44
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ILE,44
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ILE
pdbx poly seq scheme.seq id: 44
pdbx poly seq scheme.auth mon id: ILE
pdbx poly seq scheme.auth seq num: 61
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 44
pdbx poly seq scheme.pdb mon id: ILE
pdbx poly seq scheme.pdb seq num: 61
pdbx poly seq scheme.pdb strand id: A

A,1,MET,45
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,MET,45
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: MET
pdbx poly seq scheme.seq id: 45
pdbx poly seq scheme.auth mon id: MET
pdbx poly seq scheme.auth seq num: 62
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 45
pdbx poly seq scheme.pdb mon id: MET
pdbx poly seq scheme.pdb seq num: 62
pdbx poly seq scheme.pdb strand id: A

A,1,THR,46
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,THR,46
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: THR
pdbx poly seq scheme.seq id: 46
pdbx poly seq scheme.auth mon id: THR
pdbx poly seq scheme.auth seq num: 63
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 46
pdbx poly seq scheme.pdb mon id: THR
pdbx poly seq scheme.pdb seq num: 63
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,47
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,47
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 47
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 64
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 47
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 64
pdbx poly seq scheme.pdb strand id: A

A,1,ARG,48
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ARG,48
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ARG
pdbx poly seq scheme.seq id: 48
pdbx poly seq scheme.auth mon id: ARG
pdbx poly seq scheme.auth seq num: 65
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 48
pdbx poly seq scheme.pdb mon id: ARG
pdbx poly seq scheme.pdb seq num: 65
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,49
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,49
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 49
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 66
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 49
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 66
pdbx poly seq scheme.pdb strand id: A

A,1,TYR,50
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,TYR,50
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: TYR
pdbx poly seq scheme.seq id: 50
pdbx poly seq scheme.auth mon id: TYR
pdbx poly seq scheme.auth seq num: 67
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 50
pdbx poly seq scheme.pdb mon id: TYR
pdbx poly seq scheme.pdb seq num: 67
pdbx poly seq scheme.pdb strand id: A

A,1,ASP,51
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ASP,51
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ASP
pdbx poly seq scheme.seq id: 51
pdbx poly seq scheme.auth mon id: ASP
pdbx poly seq scheme.auth seq num: 68
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 51
pdbx poly seq scheme.pdb mon id: ASP
pdbx poly seq scheme.pdb seq num: 68
pdbx poly seq scheme.pdb strand id: A

A,1,GLU,52
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLU,52
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLU
pdbx poly seq scheme.seq id: 52
pdbx poly seq scheme.auth mon id: GLU
pdbx poly seq scheme.auth seq num: 69
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 52
pdbx poly seq scheme.pdb mon id: GLU
pdbx poly seq scheme.pdb seq num: 69
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,53
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,53
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 53
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 70
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 53
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 70
pdbx poly seq scheme.pdb strand id: A

A,1,GLN,54
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLN,54
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLN
pdbx poly seq scheme.seq id: 54
pdbx poly seq scheme.auth mon id: GLN
pdbx poly seq scheme.auth seq num: 71
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 54
pdbx poly seq scheme.pdb mon id: GLN
pdbx poly seq scheme.pdb seq num: 71
pdbx poly seq scheme.pdb strand id: A

A,1,GLN,55
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLN,55
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLN
pdbx poly seq scheme.seq id: 55
pdbx poly seq scheme.auth mon id: GLN
pdbx poly seq scheme.auth seq num: 72
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 55
pdbx poly seq scheme.pdb mon id: GLN
pdbx poly seq scheme.pdb seq num: 72
pdbx poly seq scheme.pdb strand id: A

A,1,HIS,56
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,HIS,56
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: HIS
pdbx poly seq scheme.seq id: 56
pdbx poly seq scheme.auth mon id: HIS
pdbx poly seq scheme.auth seq num: 73
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 56
pdbx poly seq scheme.pdb mon id: HIS
pdbx poly seq scheme.pdb seq num: 73
pdbx poly seq scheme.pdb strand id: A

A,1,ILE,57
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ILE,57
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ILE
pdbx poly seq scheme.seq id: 57
pdbx poly seq scheme.auth mon id: ILE
pdbx poly seq scheme.auth seq num: 74
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 57
pdbx poly seq scheme.pdb mon id: ILE
pdbx poly seq scheme.pdb seq num: 74
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,58
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,58
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 58
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 75
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 58
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 75
pdbx poly seq scheme.pdb strand id: A

A,1,TYR,59
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,TYR,59
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: TYR
pdbx poly seq scheme.seq id: 59
pdbx poly seq scheme.auth mon id: TYR
pdbx poly seq scheme.auth seq num: 76
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 59
pdbx poly seq scheme.pdb mon id: TYR
pdbx poly seq scheme.pdb seq num: 76
pdbx poly seq scheme.pdb strand id: A

A,1,CYS,60
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,CYS,60
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: CYS
pdbx poly seq scheme.seq id: 60
pdbx poly seq scheme.auth mon id: CYS
pdbx poly seq scheme.auth seq num: 77
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 60
pdbx poly seq scheme.pdb mon id: CYS
pdbx poly seq scheme.pdb seq num: 77
pdbx poly seq scheme.pdb strand id: A

A,1,SER,61
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,SER,61
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: SER
pdbx poly seq scheme.seq id: 61
pdbx poly seq scheme.auth mon id: SER
pdbx poly seq scheme.auth seq num: 78
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 61
pdbx poly seq scheme.pdb mon id: SER
pdbx poly seq scheme.pdb seq num: 78
pdbx poly seq scheme.pdb strand id: A

A,1,ASN,62
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ASN,62
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ASN
pdbx poly seq scheme.seq id: 62
pdbx poly seq scheme.auth mon id: ASN
pdbx poly seq scheme.auth seq num: 79
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 62
pdbx poly seq scheme.pdb mon id: ASN
pdbx poly seq scheme.pdb seq num: 79
pdbx poly seq scheme.pdb strand id: A

A,1,ASP,63
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ASP,63
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ASP
pdbx poly seq scheme.seq id: 63
pdbx poly seq scheme.auth mon id: ASP
pdbx poly seq scheme.auth seq num: 80
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 63
pdbx poly seq scheme.pdb mon id: ASP
pdbx poly seq scheme.pdb seq num: 80
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,64
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,64
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 64
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 81
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 64
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 81
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,65
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,65
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 65
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 82
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 65
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 82
pdbx poly seq scheme.pdb strand id: A

A,1,GLY,66
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLY,66
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLY
pdbx poly seq scheme.seq id: 66
pdbx poly seq scheme.auth mon id: GLY
pdbx poly seq scheme.auth seq num: 83
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 66
pdbx poly seq scheme.pdb mon id: GLY
pdbx poly seq scheme.pdb seq num: 83
pdbx poly seq scheme.pdb strand id: A

A,1,ASP,67
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ASP,67
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ASP
pdbx poly seq scheme.seq id: 67
pdbx poly seq scheme.auth mon id: ASP
pdbx poly seq scheme.auth seq num: 84
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 67
pdbx poly seq scheme.pdb mon id: ASP
pdbx poly seq scheme.pdb seq num: 84
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,68
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,68
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 68
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 85
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 68
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 85
pdbx poly seq scheme.pdb strand id: A

A,1,PHE,69
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,PHE,69
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: PHE
pdbx poly seq scheme.seq id: 69
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 69
pdbx poly seq scheme.pdb seq num: 86
pdbx poly seq scheme.pdb strand id: A

A,1,GLY,70
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLY,70
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLY
pdbx poly seq scheme.seq id: 70
pdbx poly seq scheme.auth mon id: GLY
pdbx poly seq scheme.auth seq num: 87
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 70
pdbx poly seq scheme.pdb mon id: GLY
pdbx poly seq scheme.pdb seq num: 87
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,71
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,71
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 71
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 88
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 71
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 88
pdbx poly seq scheme.pdb strand id: A

A,1,PRO,72
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,PRO,72
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: PRO
pdbx poly seq scheme.seq id: 72
pdbx poly seq scheme.auth mon id: PRO
pdbx poly seq scheme.auth seq num: 89
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 72
pdbx poly seq scheme.pdb mon id: PRO
pdbx poly seq scheme.pdb seq num: 89
pdbx poly seq scheme.pdb strand id: A

A,1,SER,73
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,SER,73
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: SER
pdbx poly seq scheme.seq id: 73
pdbx poly seq scheme.auth mon id: SER
pdbx poly seq scheme.auth seq num: 90
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 73
pdbx poly seq scheme.pdb mon id: SER
pdbx poly seq scheme.pdb seq num: 90
pdbx poly seq scheme.pdb strand id: A

A,1,PHE,74
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,PHE,74
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: PHE
pdbx poly seq scheme.seq id: 74
pdbx poly seq scheme.auth mon id: PHE
pdbx poly seq scheme.auth seq num: 91
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 74
pdbx poly seq scheme.pdb mon id: PHE
pdbx poly seq scheme.pdb seq num: 91
pdbx poly seq scheme.pdb strand id: A

A,1,SER,75
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,SER,75
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: SER
pdbx poly seq scheme.seq id: 75
pdbx poly seq scheme.auth mon id: SER
pdbx poly seq scheme.auth seq num: 92
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 75
pdbx poly seq scheme.pdb mon id: SER
pdbx poly seq scheme.pdb seq num: 92
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,76
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,76
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 76
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 93
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 76
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 93
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,77
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,77
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 77
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 94
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 77
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 94
pdbx poly seq scheme.pdb strand id: A

A,1,GLU,78
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLU,78
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLU
pdbx poly seq scheme.seq id: 78
pdbx poly seq scheme.auth mon id: GLU
pdbx poly seq scheme.auth seq num: 95
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 78
pdbx poly seq scheme.pdb mon id: GLU
pdbx poly seq scheme.pdb seq num: 95
pdbx poly seq scheme.pdb strand id: A

A,1,HIS,79
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,HIS,79
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: HIS
pdbx poly seq scheme.seq id: 79
pdbx poly seq scheme.auth mon id: HIS
pdbx poly seq scheme.auth seq num: 96
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 79
pdbx poly seq scheme.pdb mon id: HIS
pdbx poly seq scheme.pdb seq num: 96
pdbx poly seq scheme.pdb strand id: A

A,1,ARG,80
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ARG,80
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ARG
pdbx poly seq scheme.seq id: 80
pdbx poly seq scheme.auth mon id: ARG
pdbx poly seq scheme.auth seq num: 97
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 80
pdbx poly seq scheme.pdb mon id: ARG
pdbx poly seq scheme.pdb seq num: 97
pdbx poly seq scheme.pdb strand id: A

A,1,LYS,81
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LYS,81
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LYS
pdbx poly seq scheme.seq id: 81
pdbx poly seq scheme.auth mon id: LYS
pdbx poly seq scheme.auth seq num: 98
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 81
pdbx poly seq scheme.pdb mon id: LYS
pdbx poly seq scheme.pdb seq num: 98
pdbx poly seq scheme.pdb strand id: A

A,1,ILE,82
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ILE,82
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ILE
pdbx poly seq scheme.seq id: 82
pdbx poly seq scheme.auth mon id: ILE
pdbx poly seq scheme.auth seq num: 99
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 82
pdbx poly seq scheme.pdb mon id: ILE
pdbx poly seq scheme.pdb seq num: 99
pdbx poly seq scheme.pdb strand id: A

A,1,TYR,83
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,TYR,83
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: TYR
pdbx poly seq scheme.seq id: 83
pdbx poly seq scheme.auth mon id: TYR
pdbx poly seq scheme.auth seq num: 100
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 83
pdbx poly seq scheme.pdb mon id: TYR
pdbx poly seq scheme.pdb seq num: 100
pdbx poly seq scheme.pdb strand id: A

A,1,THR,84
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,THR,84
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: THR
pdbx poly seq scheme.seq id: 84
pdbx poly seq scheme.auth mon id: THR
pdbx poly seq scheme.auth seq num: 101
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 84
pdbx poly seq scheme.pdb mon id: THR
pdbx poly seq scheme.pdb seq num: 101
pdbx poly seq scheme.pdb strand id: A

A,1,MET,85
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,MET,85
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: MET
pdbx poly seq scheme.seq id: 85
pdbx poly seq scheme.auth mon id: MET
pdbx poly seq scheme.auth seq num: 102
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 85
pdbx poly seq scheme.pdb mon id: MET
pdbx poly seq scheme.pdb seq num: 102
pdbx poly seq scheme.pdb strand id: A

A,1,ILE,86
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ILE,86
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ILE
pdbx poly seq scheme.seq id: 86
pdbx poly seq scheme.auth mon id: ILE
pdbx poly seq scheme.auth seq num: 103
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 86
pdbx poly seq scheme.pdb mon id: ILE
pdbx poly seq scheme.pdb seq num: 103
pdbx poly seq scheme.pdb strand id: A

A,1,TYR,87
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,TYR,87
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: TYR
pdbx poly seq scheme.seq id: 87
pdbx poly seq scheme.auth mon id: TYR
pdbx poly seq scheme.auth seq num: 104
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 87
pdbx poly seq scheme.pdb mon id: TYR
pdbx poly seq scheme.pdb seq num: 104
pdbx poly seq scheme.pdb strand id: A

A,1,ARG,88
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ARG,88
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ARG
pdbx poly seq scheme.seq id: 88
pdbx poly seq scheme.auth mon id: ARG
pdbx poly seq scheme.auth seq num: 105
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 88
pdbx poly seq scheme.pdb mon id: ARG
pdbx poly seq scheme.pdb seq num: 105
pdbx poly seq scheme.pdb strand id: A

A,1,ASN,89
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ASN,89
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ASN
pdbx poly seq scheme.seq id: 89
pdbx poly seq scheme.auth mon id: ASN
pdbx poly seq scheme.auth seq num: 106
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 89
pdbx poly seq scheme.pdb mon id: ASN
pdbx poly seq scheme.pdb seq num: 106
pdbx poly seq scheme.pdb strand id: A

A,1,LEU,90
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,LEU,90
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: LEU
pdbx poly seq scheme.seq id: 90
pdbx poly seq scheme.auth mon id: LEU
pdbx poly seq scheme.auth seq num: 107
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 90
pdbx poly seq scheme.pdb mon id: LEU
pdbx poly seq scheme.pdb seq num: 107
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,91
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,91
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 91
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 108
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 91
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 108
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,92
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,92
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 92
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 109
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 92
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 109
pdbx poly seq scheme.pdb strand id: A

A,1,VAL,93
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,VAL,93
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: VAL
pdbx poly seq scheme.seq id: 93
pdbx poly seq scheme.auth mon id: VAL
pdbx poly seq scheme.auth seq num: 110
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 93
pdbx poly seq scheme.pdb mon id: VAL
pdbx poly seq scheme.pdb seq num: 110
pdbx poly seq scheme.pdb strand id: A

A,1,ASN,94
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,ASN,94
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: ASN
pdbx poly seq scheme.seq id: 94
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 94
pdbx poly seq scheme.pdb seq num: 111
pdbx poly seq scheme.pdb strand id: A

A,1,GLY,95
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,GLY,95
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: GLY
pdbx poly seq scheme.seq id: 95
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 95
pdbx poly seq scheme.pdb seq num: 112
pdbx poly seq scheme.pdb strand id: A

A,1,SER,96
type: pdbx poly seq scheme
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity poly seq: 1,SER,96
reference to struct asym: http://rdf.wwpdb.org/pdb/4JVE/struct_asym/A
pdbx poly seq scheme.asym id: A
pdbx poly seq scheme.entity id: 1
pdbx poly seq scheme.mon id: SER
pdbx poly seq scheme.seq id: 96
pdbx poly seq scheme.hetero: n
pdbx poly seq scheme.ndb seq num: 96
pdbx poly seq scheme.pdb seq num: 113
pdbx poly seq scheme.pdb strand id: A

http://rdf.wwpdb.org/pdb/4JVE/pdbx_struct_assembly/1
type: pdbx struct assembly
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx struct assembly.id: 1
pdbx struct assembly.details: author_defined_assembly
pdbx struct assembly.oligomeric count: 1
pdbx struct assembly.oligomeric details: monomeric
referenced by pdbx struct assembly gen: 1,A,B,C,1

1,A,B,C,1
type: pdbx struct assembly gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to pdbx struct assembly: http://rdf.wwpdb.org/pdb/4JVE/pdbx_struct_assembly/1
pdbx struct assembly gen.assembly id: 1
pdbx struct assembly gen.asym id list: A,B,C
pdbx struct assembly gen.oper expression: 1

http://rdf.wwpdb.org/pdb/4JVE/pdbx_struct_oper_list/1
type: pdbx struct oper list
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx struct oper list.id: 1
pdbx struct oper list.matrix11: 1
pdbx struct oper list.matrix12: 0
pdbx struct oper list.matrix13: 0
pdbx struct oper list.matrix21: 0
pdbx struct oper list.matrix22: 1
pdbx struct oper list.matrix23: 0
pdbx struct oper list.matrix31: 0
pdbx struct oper list.matrix32: 0
pdbx struct oper list.matrix33: 1
pdbx struct oper list.name: 1_555
pdbx struct oper list.symmetry operation: x,y,z
pdbx struct oper list.type: identity operation
pdbx struct oper list.vector1: 0
pdbx struct oper list.vector2: 0
pdbx struct oper list.vector3: 0

1,2,A
type: pdbx struct sheet hbond
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
pdbx struct sheet hbond.range id 1: 1
pdbx struct sheet hbond.range id 2: 2
pdbx struct sheet hbond.sheet id: A
pdbx struct sheet hbond.range 1 auth asym id: A
pdbx struct sheet hbond.range 1 auth atom id: O
pdbx struct sheet hbond.range 1 auth comp id: TYR
pdbx struct sheet hbond.range 1 auth seq id: 48
pdbx struct sheet hbond.range 1 label asym id: A
pdbx struct sheet hbond.range 1 label atom id: O
pdbx struct sheet hbond.range 1 label comp id: TYR
pdbx struct sheet hbond.range 1 label seq id: 31
pdbx struct sheet hbond.range 2 auth asym id: A
pdbx struct sheet hbond.range 2 auth atom id: N
pdbx struct sheet hbond.range 2 auth comp id: VAL
pdbx struct sheet hbond.range 2 auth seq id: 28
pdbx struct sheet hbond.range 2 label asym id: A
pdbx struct sheet hbond.range 2 label atom id: N
pdbx struct sheet hbond.range 2 label comp id: VAL
pdbx struct sheet hbond.range 2 label seq id: 11

http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
referenced by pdbx struct sheet hbond: 1,2,A
referenced by pdbx struct sheet hbond: 2,3,A
type: struct sheet
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
struct sheet.id: A
struct sheet.number strands: 3
referenced by struct sheet order: 2,3,A
referenced by struct sheet range: 3,A
referenced by struct sheet order: 1,2,A
referenced by struct sheet range: 1,A
referenced by struct sheet range: 2,A

2,3,A
type: pdbx struct sheet hbond
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
pdbx struct sheet hbond.range id 1: 2
pdbx struct sheet hbond.range id 2: 3
pdbx struct sheet hbond.sheet id: A
pdbx struct sheet hbond.range 1 auth asym id: A
pdbx struct sheet hbond.range 1 auth atom id: N
pdbx struct sheet hbond.range 1 auth comp id: ARG
pdbx struct sheet hbond.range 1 auth seq id: 29
pdbx struct sheet hbond.range 1 label asym id: A
pdbx struct sheet hbond.range 1 label atom id: N
pdbx struct sheet hbond.range 1 label comp id: ARG
pdbx struct sheet hbond.range 1 label seq id: 12
pdbx struct sheet hbond.range 2 auth asym id: A
pdbx struct sheet hbond.range 2 auth atom id: O
pdbx struct sheet hbond.range 2 auth comp id: VAL
pdbx struct sheet hbond.range 2 auth seq id: 108
pdbx struct sheet hbond.range 2 label asym id: A
pdbx struct sheet hbond.range 2 label atom id: O
pdbx struct sheet hbond.range 2 label comp id: VAL
pdbx struct sheet hbond.range 2 label seq id: 91

1,2,B
type: pdbx struct sheet hbond
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/B
pdbx struct sheet hbond.range id 1: 1
pdbx struct sheet hbond.range id 2: 2
pdbx struct sheet hbond.sheet id: B
pdbx struct sheet hbond.range 1 auth asym id: A
pdbx struct sheet hbond.range 1 auth atom id: N
pdbx struct sheet hbond.range 1 auth comp id: ILE
pdbx struct sheet hbond.range 1 auth seq id: 74
pdbx struct sheet hbond.range 1 label asym id: A
pdbx struct sheet hbond.range 1 label atom id: N
pdbx struct sheet hbond.range 1 label comp id: ILE
pdbx struct sheet hbond.range 1 label seq id: 57
pdbx struct sheet hbond.range 2 auth asym id: A
pdbx struct sheet hbond.range 2 auth atom id: O
pdbx struct sheet hbond.range 2 auth comp id: PHE
pdbx struct sheet hbond.range 2 auth seq id: 91
pdbx struct sheet hbond.range 2 label asym id: A
pdbx struct sheet hbond.range 2 label atom id: O
pdbx struct sheet hbond.range 2 label comp id: PHE
pdbx struct sheet hbond.range 2 label seq id: 74

http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/B
referenced by pdbx struct sheet hbond: 1,2,B
type: struct sheet
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
struct sheet.id: B
struct sheet.number strands: 2
referenced by struct sheet order: 1,2,B
referenced by struct sheet range: 2,B
referenced by struct sheet range: 1,B

http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/1
type: pdbx unobs or zero occ residues
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: PHE
pdbx unobs or zero occ residues.id: 1
pdbx unobs or zero occ residues.pdb model num: 1
pdbx unobs or zero occ residues.auth asym id: A
pdbx unobs or zero occ residues.auth comp id: PHE
pdbx unobs or zero occ residues.auth seq id: 86
pdbx unobs or zero occ residues.label asym id: A
pdbx unobs or zero occ residues.label comp id: PHE
pdbx unobs or zero occ residues.label seq id: 69
pdbx unobs or zero occ residues.occupancy flag: 1
pdbx unobs or zero occ residues.polymer flag: Y

http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/2
type: pdbx unobs or zero occ residues
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: ASN
pdbx unobs or zero occ residues.id: 2
pdbx unobs or zero occ residues.pdb model num: 1
pdbx unobs or zero occ residues.auth asym id: A
pdbx unobs or zero occ residues.auth comp id: ASN
pdbx unobs or zero occ residues.auth seq id: 111
pdbx unobs or zero occ residues.label asym id: A
pdbx unobs or zero occ residues.label comp id: ASN
pdbx unobs or zero occ residues.label seq id: 94
pdbx unobs or zero occ residues.occupancy flag: 1
pdbx unobs or zero occ residues.polymer flag: Y

http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/3
type: pdbx unobs or zero occ residues
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: GLY
pdbx unobs or zero occ residues.id: 3
pdbx unobs or zero occ residues.pdb model num: 1
pdbx unobs or zero occ residues.auth asym id: A
pdbx unobs or zero occ residues.auth comp id: GLY
pdbx unobs or zero occ residues.auth seq id: 112
pdbx unobs or zero occ residues.label asym id: A
pdbx unobs or zero occ residues.label comp id: GLY
pdbx unobs or zero occ residues.label seq id: 95
pdbx unobs or zero occ residues.occupancy flag: 1
pdbx unobs or zero occ residues.polymer flag: Y

http://rdf.wwpdb.org/pdb/4JVE/pdbx_unobs_or_zero_occ_residues/4
type: pdbx unobs or zero occ residues
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to chem comp: SER
pdbx unobs or zero occ residues.id: 4
pdbx unobs or zero occ residues.pdb model num: 1
pdbx unobs or zero occ residues.auth asym id: A
pdbx unobs or zero occ residues.auth comp id: SER
pdbx unobs or zero occ residues.auth seq id: 113
pdbx unobs or zero occ residues.label asym id: A
pdbx unobs or zero occ residues.label comp id: SER
pdbx unobs or zero occ residues.label seq id: 96
pdbx unobs or zero occ residues.occupancy flag: 1
pdbx unobs or zero occ residues.polymer flag: Y

http://rdf.wwpdb.org/pdb/4JVE/pdbx_validate_torsion/1
type: pdbx validate torsion
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx validate torsion.id: 1
pdbx validate torsion.pdb model num: 1
pdbx validate torsion.auth asym id: A
pdbx validate torsion.auth comp id: THR
pdbx validate torsion.auth seq id: 26
pdbx validate torsion.phi: -37.12
pdbx validate torsion.psi: 120.02

X-RAY DIFFRACTION,1
type: pdbx xplor file
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx xplor file.pdbx refine id: X-RAY DIFFRACTION
pdbx xplor file.serial no: 1
pdbx xplor file.param file: mdm2.param

X-RAY DIFFRACTION,2
type: pdbx xplor file
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx xplor file.pdbx refine id: X-RAY DIFFRACTION
pdbx xplor file.serial no: 2
pdbx xplor file.param file: 2206089.xprm

X-RAY DIFFRACTION,3
type: pdbx xplor file
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
pdbx xplor file.pdbx refine id: X-RAY DIFFRACTION
pdbx xplor file.serial no: 3
pdbx xplor file.param file: MSI_CNX_TOPPAR:water_rep.param

4JVE,X-RAY DIFFRACTION
type: refine
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
refine.entry id: 4JVE
refine.pdbx refine id: X-RAY DIFFRACTION
refine.b iso max: 71.39
refine.b iso mean: 28.9861
refine.b iso min: 8.41
refine.aniso B11: 0.926
refine.aniso B12: 0
refine.aniso B13: 0
refine.aniso B22: 0.926
refine.aniso B23: 0
refine.aniso B33: -1.852
refine.ls r factor r free: 0.298
refine.ls r factor r work: 0.268
refine.ls d res high: 2.3
refine.ls d res low: 30
refine.ls number reflns r free: 238
refine.ls number reflns r work: 4909
refine.ls number reflns obs: 5147
refine.ls percent reflns r free: 4.6
refine.ls percent reflns obs: 98.8
refine.occupancy max: 1
refine.occupancy min: 1
refine.pdbx r free selection details: RANDOM
refine.pdbx diffrn id: 1
refine.pdbx ls sigma f: 0
refine.pdbx method to determine struct: MOLECULAR REPLACEMENT
refine.pdbx stereochemistry target values: Engh & Huber

LAST,X-RAY DIFFRACTION
type: refine hist
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
refine hist.cycle id: LAST
refine hist.pdbx refine id: X-RAY DIFFRACTION
refine hist.d res high: 2.3
refine hist.d res low: 30
refine hist.number atoms solvent: 40
refine hist.number atoms total: 830
refine hist.pdbx number atoms ligand: 36
refine hist.pdbx number atoms nucleic acid: 0
refine hist.pdbx number atoms protein: 754

X-RAY DIFFRACTION,c mcbond it
type: refine ls restr
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
refine ls restr.pdbx refine id: X-RAY DIFFRACTION
refine ls restr.type: c_mcbond_it
refine ls restr.dev ideal: 1.511
refine ls restr.dev ideal target: 1.5

X-RAY DIFFRACTION,c scbond it
type: refine ls restr
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
refine ls restr.pdbx refine id: X-RAY DIFFRACTION
refine ls restr.type: c_scbond_it
refine ls restr.dev ideal: 2.234
refine ls restr.dev ideal target: 2

X-RAY DIFFRACTION,c mcangle it
type: refine ls restr
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
refine ls restr.pdbx refine id: X-RAY DIFFRACTION
refine ls restr.type: c_mcangle_it
refine ls restr.dev ideal: 2.358
refine ls restr.dev ideal target: 2

X-RAY DIFFRACTION,c scangle it
type: refine ls restr
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
refine ls restr.pdbx refine id: X-RAY DIFFRACTION
refine ls restr.type: c_scangle_it
refine ls restr.dev ideal: 3.318
refine ls restr.dev ideal target: 2.5

http://rdf.wwpdb.org/pdb/4JVE/reflns/1
type: reflns
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
reflns.pdbx ordinal: 1
reflns.d resolution high: 2.3
reflns.d resolution low: 30
reflns.entry id: 4JVE
reflns.number obs: 5254
reflns.observed criterion sigma i: -3
reflns.pdbx rmerge i obs: 0.078
reflns.pdbx diffrn id: 1
reflns.percent possible obs: 99.7

http://rdf.wwpdb.org/pdb/4JVE/reflns_shell/1
type: reflns shell
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reflns shell.pdbx ordinal: 1
reflns shell.rmerge i obs: 0.424
reflns shell.d res high: 2.3
reflns shell.d res low: 2.38
reflns shell.pdbx diffrn id: 1
reflns shell.percent possible all: 100

http://rdf.wwpdb.org/pdb/4JVE/software/1
type: software
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
software.pdbx ordinal: 1
software.classification: data collection
software.name: HKL-2000

http://rdf.wwpdb.org/pdb/4JVE/software/2
type: software
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
software.pdbx ordinal: 2
software.classification: phasing
software.name: AMoRE

http://rdf.wwpdb.org/pdb/4JVE/software/3
type: software
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
software.pdbx ordinal: 3
software.classification: refinement
software.name: CNS

http://rdf.wwpdb.org/pdb/4JVE/software/4
type: software
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
software.pdbx ordinal: 4
software.classification: data reduction
software.name: DENZO

http://rdf.wwpdb.org/pdb/4JVE/software/5
type: software
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
software.pdbx ordinal: 5
software.classification: data scaling
software.name: SCALEPACK

4JVE
type: struct
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
struct.entry id: 4JVE
struct.pdbx descriptor: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)
struct.title: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid

http://rdf.wwpdb.org/pdb/4JVE/struct_asym/B
type: struct asym
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/2
struct asym.id: B
struct asym.entity id: 2
struct asym.pdbx blank PDB chainid flag: N
struct asym.pdbx modified: N

http://rdf.wwpdb.org/pdb/4JVE/struct_asym/C
type: struct asym
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/3
struct asym.id: C
struct asym.entity id: 3
struct asym.pdbx blank PDB chainid flag: N
struct asym.pdbx modified: N

http://rdf.wwpdb.org/pdb/4JVE/struct_biol/1
type: struct biol
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
struct biol.id: 1

HELX P1
type: struct conf
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct conf type: HELX P
struct conf.id: HELX_P1
struct conf.beg auth asym id: A
struct conf.beg auth comp id: PRO
struct conf.beg auth seq id: 20
struct conf.beg label asym id: A
struct conf.beg label comp id: PRO
struct conf.beg label seq id: 3
struct conf.conf type id: HELX_P
struct conf.end auth asym id: A
struct conf.end auth comp id: THR
struct conf.end auth seq id: 26
struct conf.end label asym id: A
struct conf.end label comp id: THR
struct conf.end label seq id: 9
struct conf.pdbx PDB helix class: 1
struct conf.pdbx PDB helix id: 1
struct conf.pdbx PDB helix length: 7

HELX P
referenced by struct conf: HELX P1
referenced by struct conf: HELX P2
referenced by struct conf: HELX P3
referenced by struct conf: HELX P4
referenced by struct conf: HELX P5
type: struct conf type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
struct conf type.id: HELX_P

HELX P2
type: struct conf
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct conf type: HELX P
struct conf.id: HELX_P2
struct conf.beg auth asym id: A
struct conf.beg auth comp id: LYS
struct conf.beg auth seq id: 31
struct conf.beg label asym id: A
struct conf.beg label comp id: LYS
struct conf.beg label seq id: 14
struct conf.conf type id: HELX_P
struct conf.end auth asym id: A
struct conf.end auth comp id: VAL
struct conf.end auth seq id: 41
struct conf.end label asym id: A
struct conf.end label comp id: VAL
struct conf.end label seq id: 24
struct conf.pdbx PDB helix class: 1
struct conf.pdbx PDB helix id: 2
struct conf.pdbx PDB helix length: 11

HELX P3
type: struct conf
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct conf type: HELX P
struct conf.id: HELX_P3
struct conf.beg auth asym id: A
struct conf.beg auth comp id: MET
struct conf.beg auth seq id: 50
struct conf.beg label asym id: A
struct conf.beg label comp id: MET
struct conf.beg label seq id: 33
struct conf.conf type id: HELX_P
struct conf.end auth asym id: A
struct conf.end auth comp id: LYS
struct conf.end auth seq id: 64
struct conf.end label asym id: A
struct conf.end label comp id: LYS
struct conf.end label seq id: 47
struct conf.pdbx PDB helix class: 1
struct conf.pdbx PDB helix id: 3
struct conf.pdbx PDB helix length: 15

HELX P4
type: struct conf
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct conf type: HELX P
struct conf.id: HELX_P4
struct conf.beg auth asym id: A
struct conf.beg auth comp id: ASP
struct conf.beg auth seq id: 80
struct conf.beg label asym id: A
struct conf.beg label comp id: ASP
struct conf.beg label seq id: 63
struct conf.conf type id: HELX_P
struct conf.end auth asym id: A
struct conf.end auth comp id: LEU
struct conf.end auth seq id: 85
struct conf.end label asym id: A
struct conf.end label comp id: LEU
struct conf.end label seq id: 68
struct conf.pdbx PDB helix class: 1
struct conf.pdbx PDB helix id: 4
struct conf.pdbx PDB helix length: 6

HELX P5
type: struct conf
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct conf type: HELX P
struct conf.id: HELX_P5
struct conf.beg auth asym id: A
struct conf.beg auth comp id: GLU
struct conf.beg auth seq id: 95
struct conf.beg label asym id: A
struct conf.beg label comp id: GLU
struct conf.beg label seq id: 78
struct conf.conf type id: HELX_P
struct conf.end auth asym id: A
struct conf.end auth comp id: ASN
struct conf.end auth seq id: 106
struct conf.end label asym id: A
struct conf.end label comp id: ASN
struct conf.end label seq id: 89
struct conf.pdbx PDB helix class: 1
struct conf.pdbx PDB helix id: 5
struct conf.pdbx PDB helix length: 12

disulf1
type: struct conn
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct conn type: disulf
struct conn.id: disulf1
struct conn.conn type id: disulf
struct conn.pdbx dist value: 2.684
struct conn.ptnr1 auth asym id: A
struct conn.ptnr1 auth comp id: CYS
struct conn.ptnr1 auth seq id: 77
struct conn.ptnr1 label asym id: A
struct conn.ptnr1 label atom id: SG
struct conn.ptnr1 label comp id: CYS
struct conn.ptnr1 label seq id: 60
struct conn.ptnr1 symmetry: 1_555
struct conn.ptnr2 auth asym id: A
struct conn.ptnr2 auth comp id: CYS
struct conn.ptnr2 auth seq id: 77
struct conn.ptnr2 label asym id: A
struct conn.ptnr2 label atom id: SG
struct conn.ptnr2 label comp id: CYS
struct conn.ptnr2 label seq id: 60
struct conn.ptnr2 symmetry: 7_646

disulf
referenced by struct conn: disulf1
type: struct conn type
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
struct conn type.id: disulf

4JVE
type: struct keywords
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
struct keywords.entry id: 4JVE
struct keywords.pdbx keywords: LIGASE/LIGASE INHIBITOR
struct keywords.text: p53, protein-protein interaction, LIGASE-LIGASE INHIBITOR complex

http://rdf.wwpdb.org/pdb/4JVE/struct_ref/1
type: struct ref
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entity: http://rdf.wwpdb.org/pdb/4JVE/entity/1
struct ref.id: 1
struct ref.db code: MDM2_HUMAN
struct ref.db name: UNP
struct ref.entity id: 1
struct ref.pdbx align begin: 18
struct ref.pdbx db accession: Q00987
struct ref.pdbx seq one letter code: QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHR KIYTMIYRNLVVVN
link to uniprot: uniprot:Q00987
referenced by struct ref seq: http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq/1

uniprot:Q00987

http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq/1
type: struct ref seq
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct ref: http://rdf.wwpdb.org/pdb/4JVE/struct_ref/1
struct ref seq.align id: 1
struct ref seq.db align beg: 18
struct ref seq.db align end: 111
struct ref seq.pdbx PDB id code: 4JVE
struct ref seq.pdbx auth seq align beg: 18
struct ref seq.pdbx auth seq align end: 111
struct ref seq.pdbx db accession: Q00987
struct ref seq.pdbx strand id: A
struct ref seq.ref id: 1
struct ref seq.seq align beg: 1
struct ref seq.seq align end: 94
referenced by struct ref seq dif: http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq_dif/2
referenced by struct ref seq dif: http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq_dif/1

http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq_dif/1
type: struct ref seq dif
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct ref seq: http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq/1
struct ref seq dif.pdbx ordinal: 1
struct ref seq dif.align id: 1
struct ref seq dif.details: EXPRESSION TAG
struct ref seq dif.mon id: GLY
struct ref seq dif.pdbx auth seq num: 112
struct ref seq dif.pdbx pdb id code: 4JVE
struct ref seq dif.pdbx pdb strand id: A
struct ref seq dif.pdbx seq db accession code: Q00987
struct ref seq dif.pdbx seq db name: UNP
struct ref seq dif.seq num: 95

http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq_dif/2
type: struct ref seq dif
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct ref seq: http://rdf.wwpdb.org/pdb/4JVE/struct_ref_seq/1
struct ref seq dif.pdbx ordinal: 2
struct ref seq dif.align id: 1
struct ref seq dif.details: EXPRESSION TAG
struct ref seq dif.mon id: SER
struct ref seq dif.pdbx auth seq num: 113
struct ref seq dif.pdbx pdb id code: 4JVE
struct ref seq dif.pdbx pdb strand id: A
struct ref seq dif.pdbx seq db accession code: Q00987
struct ref seq dif.pdbx seq db name: UNP
struct ref seq dif.seq num: 96

1,2,A
type: struct sheet order
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
struct sheet order.range id 1: 1
struct sheet order.range id 2: 2
struct sheet order.sheet id: A
struct sheet order.sense: anti-parallel

2,3,A
type: struct sheet order
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
struct sheet order.range id 1: 2
struct sheet order.range id 2: 3
struct sheet order.sheet id: A
struct sheet order.sense: anti-parallel

1,2,B
type: struct sheet order
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/B
struct sheet order.range id 1: 1
struct sheet order.range id 2: 2
struct sheet order.sheet id: B
struct sheet order.sense: anti-parallel

1,A
type: struct sheet range
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
struct sheet range.id: 1
struct sheet range.sheet id: A
struct sheet range.beg auth asym id: A
struct sheet range.beg auth comp id: TYR
struct sheet range.beg auth seq id: 48
struct sheet range.beg label asym id: A
struct sheet range.beg label comp id: TYR
struct sheet range.beg label seq id: 31
struct sheet range.end auth asym id: A
struct sheet range.end auth comp id: THR
struct sheet range.end auth seq id: 49
struct sheet range.end label asym id: A
struct sheet range.end label comp id: THR
struct sheet range.end label seq id: 32

2,A
type: struct sheet range
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
struct sheet range.id: 2
struct sheet range.sheet id: A
struct sheet range.beg auth asym id: A
struct sheet range.beg auth comp id: LEU
struct sheet range.beg auth seq id: 27
struct sheet range.beg label asym id: A
struct sheet range.beg label comp id: LEU
struct sheet range.beg label seq id: 10
struct sheet range.end auth asym id: A
struct sheet range.end auth comp id: PRO
struct sheet range.end auth seq id: 30
struct sheet range.end label asym id: A
struct sheet range.end label comp id: PRO
struct sheet range.end label seq id: 13

3,A
type: struct sheet range
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/A
struct sheet range.id: 3
struct sheet range.sheet id: A
struct sheet range.beg auth asym id: A
struct sheet range.beg auth comp id: LEU
struct sheet range.beg auth seq id: 107
struct sheet range.beg label asym id: A
struct sheet range.beg label comp id: LEU
struct sheet range.beg label seq id: 90
struct sheet range.end auth asym id: A
struct sheet range.end auth comp id: VAL
struct sheet range.end auth seq id: 109
struct sheet range.end label asym id: A
struct sheet range.end label comp id: VAL
struct sheet range.end label seq id: 92

1,B
type: struct sheet range
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/B
struct sheet range.id: 1
struct sheet range.sheet id: B
struct sheet range.beg auth asym id: A
struct sheet range.beg auth comp id: HIS
struct sheet range.beg auth seq id: 73
struct sheet range.beg label asym id: A
struct sheet range.beg label comp id: HIS
struct sheet range.beg label seq id: 56
struct sheet range.end auth asym id: A
struct sheet range.end auth comp id: ILE
struct sheet range.end auth seq id: 74
struct sheet range.end label asym id: A
struct sheet range.end label comp id: ILE
struct sheet range.end label seq id: 57

2,B
type: struct sheet range
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct sheet: http://rdf.wwpdb.org/pdb/4JVE/struct_sheet/B
struct sheet range.id: 2
struct sheet range.sheet id: B
struct sheet range.beg auth asym id: A
struct sheet range.beg auth comp id: PHE
struct sheet range.beg auth seq id: 91
struct sheet range.beg label asym id: A
struct sheet range.beg label comp id: PHE
struct sheet range.beg label seq id: 74
struct sheet range.end auth asym id: A
struct sheet range.end auth comp id: SER
struct sheet range.end auth seq id: 92
struct sheet range.end label asym id: A
struct sheet range.end label comp id: SER
struct sheet range.end label seq id: 75

AC1
type: struct site
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
struct site.id: AC1
struct site.details: BINDING SITE FOR RESIDUE 1MQ A 201
struct site.pdbx evidence code: Software
struct site.pdbx num residues: 10
referenced by struct site gen: 10,AC1
referenced by struct site gen: 1,AC1
referenced by struct site gen: 2,AC1
referenced by struct site gen: 3,AC1
referenced by struct site gen: 4,AC1
referenced by struct site gen: 5,AC1
referenced by struct site gen: 6,AC1
referenced by struct site gen: 7,AC1
referenced by struct site gen: 8,AC1
referenced by struct site gen: 9,AC1

1,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 1
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: ARG
struct site gen.auth seq id: 29
struct site gen.label asym id: A
struct site gen.label comp id: ARG
struct site gen.label seq id: 12
struct site gen.pdbx num res: 10
struct site gen.symmetry: 6_445

2,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 2
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: LEU
struct site gen.auth seq id: 54
struct site gen.label asym id: A
struct site gen.label comp id: LEU
struct site gen.label seq id: 37
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

3,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 3
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: PHE
struct site gen.auth seq id: 55
struct site gen.label asym id: A
struct site gen.label comp id: PHE
struct site gen.label seq id: 38
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

4,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 4
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: LEU
struct site gen.auth seq id: 57
struct site gen.label asym id: A
struct site gen.label comp id: LEU
struct site gen.label seq id: 40
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

5,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 5
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: GLY
struct site gen.auth seq id: 58
struct site gen.label asym id: A
struct site gen.label comp id: GLY
struct site gen.label seq id: 41
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

6,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 6
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: GLN
struct site gen.auth seq id: 59
struct site gen.label asym id: A
struct site gen.label comp id: GLN
struct site gen.label seq id: 42
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

7,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 7
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: MET
struct site gen.auth seq id: 62
struct site gen.label asym id: A
struct site gen.label comp id: MET
struct site gen.label seq id: 45
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

8,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 8
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: ILE
struct site gen.auth seq id: 99
struct site gen.label asym id: A
struct site gen.label comp id: ILE
struct site gen.label seq id: 82
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

9,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 9
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: HOH
struct site gen.auth seq id: 314
struct site gen.label asym id: C
struct site gen.label comp id: HOH
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

10,AC1
type: struct site gen
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to struct site: AC1
struct site gen.id: 10
struct site gen.site id: AC1
struct site gen.auth asym id: A
struct site gen.auth comp id: HOH
struct site gen.auth seq id: 336
struct site gen.label asym id: C
struct site gen.label comp id: HOH
struct site gen.pdbx num res: 10
struct site gen.symmetry: 1_555

4JVE
type: symmetry
of datablock: Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
reference to entry: 4JVE
symmetry.entry id: 4JVE
symmetry.int tables number: 92
symmetry.space group name H-M: P 41 21 2