Crystal structure of the N-terminal region of the human ryanodine receptor 2

Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias.

RYR-2, RyR2, hRYR-2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, Type 2 ryanodine receptor

MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQE
MLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWW
TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH
MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKE
KADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMD
DGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR
ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLIS
RLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGR

20 mM TRIS-HCl, 150 mM NaCl, 10% glycerol, 7mM mercaptoethanol, 1 mM CHAPS, 0.1% betaine, 100 mM HEPES, 200 mM ammonium formate, 21% PEG 3350, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K

CRYSTAL STRUCTURE OF THE N-TERMINAL THREE DOMAINS OF THE SKELETAL MUSCLE RYANODINE RECEPTOR (RYR1)

CRYSTAL STRUCTURE OF RABBIT RYANODINE RECEPTOR 1 (RESIDUES 1-536) DISEASE MUTANT C36R

Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R

Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant D61N

Crystal structure of rabbit ryanodine receptor 1 (residues 1-559) disease mutant R45C

Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant L14R

Crystal structure of mouse Ryanodine Receptor 2 (residues 1-217)

Crystal structure of mouse Ryanodine Receptor 2 mutant V186M

Crystal structure of mouse Ryanodine Receptor 2 N-terminal domain (1-217) disease mutant A77V

Crystal structure of rabbit ryanodine receptor 1 N-terminal domain (9-205)

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT