Crystal structure of Mycobacterium tuberculosis CarD
Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture.
RNA polymerase-binding transcription factor CarD
MIFKVGDTVVYPHHGAALVEAIETRTIKGEQKEYLVLKVAQGDLTVRVPAENAEYVGVRDVVGQEGLDKVFQVLRAPHTE EPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDQERGLSAGEKRMLAKARQILVGELALAESTDDAKAETILDEVLAA AALEHHHHHH
1.5M Lithium sulphate, 0.1M HEPES pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 291K
Tudor like domain, five helical fold, RNA polymerase binding, Transcription regulation, TRANSCRIPTION
MIFKVGDTVVYPHHGAALVEAIETRTIKGEQKEYLVLKVAQGDLTVRVPAENAEYVGVRDVVGQEGLDKVFQVLRAPHTE EPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDQERGLSAGEKRMLAKARQILVGELALAESTDDAKAETILDEVLAA AS