Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

DNA double-strand break repair protein Mre11

HHHHHHMKFAHLADIHLGYEQFHKPQREEEFAEAFKNALEIAVQENVDFILIAGDLFHSSRPSPGTLKKAIALLQIPKEH
SIPVFAIEGNHDRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLTSERLGNGEYLVKGVYKDLEIHGMKYMSSAWFEAN
KEILKRLFRPTDNAILMLHQGVREVSEARGEDYFEIGLGDLPEGYLYYARGHIHKRYETSYSGSPVVYPGSLERWDFGDY
EVRYEWDGIKFKERYGVNKGFYIVEDFKPRFVEIKVRPFIDVKIKGSEEEIRKAIKRLIPLIPKNAYVRLNIGWRKPFDL
TEIKELLNVEYLKIDTWRI

JCSG core 2 suite Qiagen cond number 7

ratio 1/1 protein solution-cryst solution, pH 9, VAPOR DIFFUSION, HANGING DROP, temperature 288K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

nuclease enzyme, double-strand break repair, Rad50, NBS1, mutation L204R, DNA BINDING PROTEIN

MKFAHLADIHLGYEQFHKPQREEEFAEAFKNALEIAVQENVDFILIAGDLFHSSRPSPGTLKKAIALLQIPKEHSIPVFA
IEGNHDRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLTSERLGNGEYLVKGVYKDLEIHGMKYMSSAWFEANKEILKR
LFRPTDNAILMLHQGVREVSEARGEDYFEIGLGDLPEGYLYYALGHIHKRYETSYSGSPVVYPGSLERWDFGDYEVRYEW
DGIKFKERYGVNKGFYIVEDFKPRFVEIKVRPFIDVKIKGSEEEIRKAIKRLIPLIPKNAYVRLNIGWRKPFDLTEIKEL
LNVEYLKIDTWRI