Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0355

PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3

SMKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSS
HFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPE
YKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYF
ASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVP
QGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVH

2.1M DL-Malic Acid, 0.05M Bis-tris-propane, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K

The same protein complexed with 3-aminobenzamide.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

NAD, ADP-RIBOSE, PARP3, ARTD3, ARTD TRANSFERASE DOMAIN, ADP-RIBOSYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE

KRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHF
YTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYK
VIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFAS
ENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQG
QPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVH