Crystal structure of a autoimmune TCR-MHC complex

Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.

NAG B 201 HAS WRONG CHIRALITY AT ATOM C1

DIVADHVASCGVNLYQFYGPSGQYTHEFDGDEQFYVDLERKETAWRWPEFSKFGGFDPQGALRNMAVAKHNLNIMIKRYN
STAATNEVPEVTVFSKSPVTLGQPNTLICLVDNIFPPVVNITWLSNGQSVTEGVSETSFLSKSDHSFFKISYLTFLPSAD
EIYDCKVEHWGLDQPLLKHWEPE

EGRDSPEDFVYQFKGLCYFTNGTERVRGVTRHIYNREEYVRFDSDVGVYRAVTPQGRPVAEYWNSQKEVLEGARASVDRV
CRHNYEVAYRGILQRRVEPTVTISPSRTEALNHHNLLICSVTDFYPSQIKVRWFRNDQEETAGVVSTPLIRNGDWTFQIL
VMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSESAQSK

MKGENVEQHPSTLSVQEGDSAVIKCTYSDSASNYFPWYKQELGKRPQLIIDIRSNVGEKKDQRIAVTLNKTAKHFSLHIT
ETQPEDSAVYFCAASSFGNEKLTFGTGTRLTIIPNIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITD
KCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSS

MKDRLLMLFAKDVVSRNGGSGGGGGGAGVSQTPSNKVTEKGKYVELRCDPISGHTALYWYRQSLGQGPEFLIYFQGTGAA
DDSGLPNDRFFAVRPEGSVSTLKIQRTERGDSAVYLCATSALGDTQYFGPGTRLTVLEDLKNVFPPEVAVFEPSEAEISH
TQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGL
SENDEWTQDRAKPVTQIVSAEAWGRADS

alpha chain, HLA-DQ1, HLA-DQA1, MHC CLASS II MOLECULE

beta chain, HLA-DQ1, HLA-DQB1, MHC CLASS II MOLECULE

0.1% Ammonium sulphate, 12% peg 6000, 0.1M Sodium citrate, pH 6.1, hanging drop vapor diffusion, temperature 295K

RESIDUES 3-17 ARE A PEPTIDE FROM PSEUDOMONAS, COVALENTLY ATTACHED TO N-TERM OF TCR BETA CHAIN

MHC class II HLA-DQ-alpha chain, MHC class II antigen, TCR Hy.1B11 alpha chain, TCR Hy.1B11 beta chain

immune complex, peptide antigen presentation, multiple sclerosis, autoimmunity, IMMUNE SYSTEM