Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae complexed with IMP and mycophenolic acid

Center for Structural Genomics of Infectious Diseases (CSGID)

6-(1,3-DIHYDRO-7-HYDROXY-5-METHOXY-4-METHYL-1-OXOISOBENZOFURAN-6-YL)-4-METHYL-4-HEXANOIC ACID

(MSE)H(MSE)LRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIP(MSE)VSAS(MSE)DTVTEARLAIALA
QEGGIGFIHKN(MSE)SIEQQAAQVHQVKIFEAGVVTHPVTVRPEQTIADV(MSE)ELTHYHGFAGFPVVTENNELVGII
TGRDVRFVTDLTKSVAAV(MSE)TPKERLATVKEGATGAEVQEK(MSE)HKARVEKILVVNDEFQLKG(MSE)ITAKDFH
KAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALVEAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAE
GARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQITAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCV
(MSE)VGS(MSE)FAGTEEAPGEVILYQGRSYKAYRG(MSE)GSLGA(MSE)SKGSSDRYFQTDNAADKLVPEGIEGRIA
YKGHLKEIIHQQ(MSE)GGLRSC(MSE)GLTGSATVEDLRTKAQFVRISGAG(MSE)KESHVHDVQITKEAPNYRLGGEN
LYFQ

MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGFAGFPVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKER
LATVKEGATGAEVQEKMHKARVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALV
EAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGS
SDRYFQTDNAADKLVPEGIEGRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQIT
KEAPNYRLGGENLYFQ

1 M sodium/potassium phosphate, 0.01 M IMP, 0.01 M mycophenolic acid, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 289K

Center for Structural Genomics of Infectious Diseases
NIAID, National Institute of Allergy and Infectious Diseases

Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant

Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP

Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP and mycophenolic acid.

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT. U VALUES: WITH TLS ADDED

Inosine-5'-monophosphate dehydrogenase (E.C.1.1.1.205)

structural genomics, IMPDH, IMP, mycophenolic acid, MOA, NIAID, National Institute of Allergy and Infectious Diseases, Center for Structural Genomics of Infectious Diseases, CSGID, OXIDOREDUCTASE

MHMLRIAKEALTFDDVLLVPAHSTVLPNTADLRTRLTKNIALNIPMVSASMDTVTEARLAIALAQEGGIGFIHKNMSIEQ
QAAQVHQVKIFEAGVVTHPVTVRPEQTIADVMELTHYHGFAGFPVVTENNELVGIITGRDVRFVTDLTKSVAAVMTPKER
LATVKEGATGAEVQEKMHKARVEKILVVNDEFQLKGMITAKDFHKAESKPNACKDEQGRLRVGAAVGAAPGNEERVKALV
EAGVDVLLIDSSHGHSEGVLQRIRETRAAYPHLEIIGGNVATAEGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQI
TAIADAAGVANEYGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEVILYQGRSYKAYRGMGSLGAMSKGS
SDRYFQTDNAADKLVPEGIEGRIAYKGHLKEIIHQQMGGLRSCMGLTGSATVEDLRTKAQFVRISGAGMKESHVHDVQIT
KEAPNYRLG