Crystal Structure of Thermus thermophilus HB8 CasA

Crystal Structure of the Largest Subunit of a Bacterial RNA-guided Immune Complex and Its Role in DNA Target Binding.

MGSLEKFNLIDEPWIPVLKGGRVVEVGIGEALLRAHEFARIETPSPLEEAVLHRLLLAVLHRALSGPRCPEDVLDWWRKG
GFPQDPIRDYLNRFRDRFFLFHPEAPFLQVADLPEENPLPWSKLLPELASGNNPTLFDHTTEENLPKATYAQAARALLVH
QAFAPGGLLRRYGVGSAKDAPVARPALFLPTGQNLLETLLLNLVPYTPEDDAPIWEVPPLRLGDLEGARTKWPLTGRTRV
YTWPARGVRLLDEGDGVRFMGYGPGVEPLEATHRDPMVAQRLDAKGNLLVLRLSEERSFWRDFSAMLPRQGGKVAATLEH
AENLQGELEDEGLEGRITLRVLGQVSDQAKVLDIRREVYPLPSGLLTPKAEENLEKALKMAEELGQGLKHLAQEVAKAVV
GERDRGHGRSPYLEELTKLANSLPLERLYWHALDGAFPRFFARVEEEASLDLWREALRGAALEAWKATRRFLGTGARHLK
ALAQGEQEFGRLLGELGEEVRT

2.3 M sodium acetate, 0.1 M MOPS, pH 7.4, VAPOR DIFFUSION, SITTING DROP, temperature 300K

four helix bundle, cascade complex, IMMUNE SYSTEM

chain A and (resseq 5:128 or resseq 143:404 or resseq 410:496 )

chain B and (resseq 5:128 or resseq 143:404 or resseq 410:496 )