Crystal structure of saposin A in complex with lauryldimethylamine-N-oxide (LDAO)
Structure of saposin A lipoprotein discs.
MGSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNL CES
1.6 M trisodium citrate, pH 6.5, VAPOR DIFFUSION, temperature 300K
ALTHOUGH THE REAL SPACE R VALUE FOR SOME OF THE LDA RESIDUES ARE HIGH, THESE LDAO DETERGENT MOLECULES (RESIDUE NAME IS LDA) ARE PART OF A MICELLE-TYPE STRUCTURE, AND THE OBSERVED DENSITY FOR THESE LIGANDS IS COMPLETELY CONSISTENT WITH THE PACKING REQUIREMENTS OF THE NEIGHBORING LDA MOLECULES.
HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES: RESIDUAL ONLY
saposin fold, sphingolipid activator protein, galactosylceramide, lauryldimethylamine-N-oxide, lipid, detergent, lysosome, LIPID BINDING PROTEIN
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCE S