Human DPP1 in complex with (2S)-N-((1S)-1-cyano-2-(4-(4-cyanophenyl) phenyl)ethyl)piperidine-2-carboxamide

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.

DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN

DIPEPTIDYL PEPTIDASE I EXCLUSION DOMAIN CHAIN, CATHEPSIN C, CATHEPSIN J, DIPEPTIDYL PEPTIDASE I, DPP-I, DPPI, DIPEPTIDYL TRANSFERASE

DIPEPTIDYL PEPTIDASE I HEAVY CHAIN, CATHEPSIN C, CATHEPSIN J, DIPEPTIDYL PEPTIDASE I, DPP-I, DPPI, DIPEPTIDYL TRANSFERASE

DIPEPTIDYL PEPTIDASE I LIGHT CHAIN, CATHEPSIN C, CATHEPSIN J, DIPEPTIDYL PEPTIDASE I, DPP-I, DPPI, DIPEPTIDYL TRANSFERASE

DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAF
FKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGT

HLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGK
YAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYH
HTGLR

21% PEG3350, 200MM AMSO4, 100MM NA ACCETATE PH 4.5

HUMAN DPP1 IN COMPLEX WITH (2S)-2-AMINO-N-((1S)-1 -CYANO-2-(4-PHENYLPHENYL)ETHYL)BUTANAMIDE

HUMAN DPP1 IN COMPLEX WITH 4-AMINO-N-((1S)-1-CYANO -2-(4-(4-CYANOPHENYL)PHENYL)ETHYL)TETRAHYDROPYRAN-4- CARBOXAMIDE

HUMAN DPP1 IN COMPLEX WITH (2S,4S)-N-((1S)-1-CYANO -2-(4-(4-CYANOPHENYL)PHENYL)ETHYL)-4-HYDROXY- PIPERIDINE-2-CARBOXAMIDE

SHEET
DETERMINATION METHOD: DSSP
THE SHEETS PRESENTED AS "AA" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY
A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.

THE SHEETS PRESENTED AS "DA" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY
A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES WITH TLS ADDED