Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I

Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.

ETGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRFSRAGATISAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQ
PEMDPKPCLTVLGKAKRAVQRGATAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHR
PPRQPTEYFDGTHHHHHHHHHH

ETGGTNPICKGCLSCSKDNGCLRCQPKLFFYLRREGMRQYGECLQSCPPGYYGVRGPDMNRCSRCRIENCDSCFSRDFCI
KCKSGFYSHKGQCFEECPEGFAPLDDTMVCVDGTKHHHHHH

ZEBRAFISH ZNRF3 ECTODOMAIN CRYSTAL FORM I

ZEBRAFISH ZNRF3 ECTODOMAIN CRYSTAL FORM II

MOUSE ZNRF3 ECTODOMAIN CRYSTAL FORM V, DISULFIDE-BRIDGED S90C VARIANT

XENOPUS ZNRF3 ECTODOMAIN CRYSTAL FORM II

MOUSE ZNRF3 ECTODOMAIN IN COMPLEX WITH MOUSE RSPO2 FU1 -FU2 CRYSTAL FORM I

MOUSE ZNRF3 ECTODOMAIN IN COMPLEX WITH XENOPUS RSPO2 FU1-FU2 (SELENO MET) CRYSTAL FORM I

MOUSE ZNRF3 ECTODOMAIN IN COMPLEX WITH XENOPUS RSPO2 FU1-FU2 (SELENO MET) CRYSTAL FORM II

XENOPUS ZNRF3 ECTODOMAIN IN COMPLEX WITH XENOPUS RSPO2 FU1-FU2 CRYSTAL FORM II

XENOPUS RNF43 ECTODOMAIN IN COMPLEX WITH XENOPUS RSPO2 FU1-FU2

SHEET
DETERMINATION METHOD: DSSP
THE SHEETS PRESENTED AS "AA" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 7-STRANDED BARREL THIS IS REPRESENTED BY
A 8-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.

THE SHEETS PRESENTED AS "CA" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 7-STRANDED BARREL THIS IS REPRESENTED BY
A 8-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 (E.C.6.3.2.-), R-SPONDIN-2

LIGASE-SIGNALING PROTEIN COMPLEX, WNT, RNF43, LGR4, LGR5, LGR6, RSPO, R-SPONDIN, R-SPO, RSPO1, RSPO3, RSPO4, RECEPTOR, MEMBRANE, SIGNALLING