11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice.

CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1

11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-DH, 11-BETA-HSD1,11B-HYDROXYSTEROID DEHYDROGENASE TYPE 1

NEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV
AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAY
SASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRW
TTLLIRNPSRKILEELYSTSYNMDRFINK

IDEAL-DIST CONTACT TERM CONTACT SETUP. ALL ATOMS HAVE CCP4 ATOM TYPE FROM LIBRARY

OXIDOREDUCTASE, CNS PENETRATION, STRUCTURE-BASED DESIGN