Architecture and DNA recognition elements of the Fanconi anemia FANCM- FAAP24 complex

Architecture and DNA Recognition Elements of the Fanconi Anemia Fancm-Faap24 Complex.

FANCONI ANEMIA-ASSOCIATED PROTEIN OF 24 KDA

PROTEIN FACM, ATP-DEPENDENT RNA HELICASE FANCM, FANCONI ANE MIA-ASSOCIATED POLYPEPTIDE OF 250 KDA, FAAP250, PROTEIN HEF ORTHOL OG, FANCM

GSGSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNS
VNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQR
KNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQM
LPNDLNQDRLKSDI

GSHMEKNPPDDTGPVHVPLGHIVANEKWRGSQLAEEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGNGYRKRLV
RVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEP
SLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQP

18%W/V PEG 3350, 0.2M CALCIUM ACETATE, 0.01M BARIUM CHLORIDE., pH 8.0

GSGS FROM VECTOR AT N-TERMINUS
GSH FROM VECTOR AT N-TERMINUS
SYNTHETIC DNA CONSTRUCT

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. RESIDUAL U VALUES ONLY. CHAIN A RESIDUES 1799-1817, 1963-1968, 2036-2048 HAVE NO VISIBLE ELECTRON DENSITY CHAIN B RESIDUES 1-11, 147-153 HAVE NO VISIBLE ELECTRON DENSITY.

FANCONI ANEMIA GROUP M PROTEIN (E.C.3.6.4.13), FANCONI ANEMIA-ASSOCIATED PROTEIN OF 24 KDA

HYDROLASE-DNA COMPLEX, DNA BINDING, PSEUDO-NUCLEASE