Mcl-1 bound to alpha beta Puma BH3 peptide 2

(3S)-3-amino-6-[(diaminomethylidene)amino]hexanoic acid

Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins.

FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG
FUSION PROTEIN OF MOUSE MCL-1, RESIDUES 152-189 AND HUMAN MCL-1, RESIDUES 209-327

BCL-2-RELATED PROTEIN EAT/MCL1, BCL-2-LIKE PROTEIN 3, BCL2- L-3, BCL-2-RELATED PROTEIN EAT/MCL1, MCL1/EAT, MCL-1 BCL-2-LIKE PROTEIN 3, BCL2-L-3, BCL-2-RELATED PROTEIN EAT/MCL1, MCL1/EAT

GPLGSEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKS
LSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLE
GG

0.1M HEPES, PH7.5 1M SODIUM ACETATE, 0.05M CADMIUM SULPHATE

MCL-1 BOUND TO ALPHA BETA PUMA BH3 PEPTIDE 3

BCL-XL BOUND TO ALPHA BETA PUMA BH3 PEPTIDE 5

HELIX
DETERMINATION METHOD: AUTHOR PROVIDED.