Discovery and Optimization of a Novel Series of Potent Mutant B-Raf V600E Selective Kinase Inhibitors.

EPHB4 RECEPTOR TYROSINE KINASE, HEPATOMA TRANSMEMBRANE KINASE, TYROSINE-PROTEIN KINASE TYRO11

DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNII
RLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVS
DFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDY
RLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLL

CRYSTAL STRUCTURE AND THERMODYNAMIC CHARACTERIZATION OF THEEPHB4 RECEPTOR IN COMPLEX WITH AN EPHRIN-B2 ANTAGONISTPEPTIDE REVEALS THE DETERMINANTS FOR RECEPTOR SPECIFICITY

COMPLEX OF THE EPHB4 KINASE DOMAIN WITH AN OXINDOLE INHIBITOR

Y774E MUTATION NOT SEEN IN ELECTRON DENSITY