The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety
Eif4E3 Acts as a Tumor Suppressor by Utilizing an Atypical Mode of Methyl-7-Guanosine CAP Recognition.
EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3
EIF4E3, EIF-4E TYPE 3, EIF-4E3, EIF4E TYPE 3, EIF4E-3
MALPPAAAPPGANEPLDKALSALPPEPGGVPLHSPWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTS LPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEIIGVSVSVRDREDVVQV WNVNASLVGEATVLEKIHQLLPHIAFKAVFYKPHEEHHAFEGGRGKH
SOLUTION STRUCTURE OF EIF4E3 IN COMPLEX WITH M7GDP
50MM PHOSPHATE, 100MM NACL, 100UM TCEP, NAN3, 7% D2O