Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity

Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.

Complexity and Simplicity in the Biosynthesis of Enediyne Natural Products.

RPHPDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAE
GGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHLLGDADAGTGSDPDSGVKPAEPVDTAVAQPAIIADSLA
GIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVA
VDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADE
DPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPF
FAGRFTRPFDRDREREFLVNP

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

TRANSFERASE, POLYKETIDE SYNTHASE, ACYLTRANSFERASE, DYNEMICIN