Crystal structures of Escherichia coli IspH in complex with TMBPP a potent inhibitor of the methylerythritol phosphate pathway

(2E)-3-methyl-4-sulfanylbut-2-en-1-yl trihydrogen diphosphate

Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials.

4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE

ISPH, 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE (E)-4-MERCAPTO-3-METHYL-BUT-2-EN- 1-YL DIPHOSPHATE

MRGSHHHHHHGSACELMQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQISEVP
DGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLV
ESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKN
SSNSNRLAELAQRMGKRAFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIVFEV
PKELRVDIREVD

CRYSTAL STRUCTURES OF ESCHERICHIA COLI ISPH IN COMPLEX WITH AMBPP A POTENT INHIBITOR OF THE METHYLERYTHRITOL PHOSPHATE PATHWAY

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES WITH TLS ADDED

OXIDOREDUCTASE, MEP PATHWAY, INHIBITORS, 4FE-4S CLUSTER