The Solution Structure of Monomeric Hepatitis C Virus p7 Yields Potent Inhibitors of Virion Release
Structure-Guided Design Affirms Inhibitors of Hepatitis C Virus P7 as a Viable Class of Antivirals Targeting Virion Release
Structural and Functional Characterisation of the Hepititis C Virus Proteins P7, Ns2-3 and Ns5A
FLAG TAG AT RESIDUES UPTO AND INCLUDING RESIDUE 18
GPLGSPEFAAMDYKDDDDKALENLVVLNAASVAGAHGILSFLVFFCAAWYIKGRLAPGAAYAFYGVWPLLLLLLALPPRA YAAAAS
HELIX DETERMINATION METHOD: AUTHOR PROVIDED.
THE STRUCTURE WAS DETERMINED USING TRIPLE-RESONANCE NMR SPECTROSCOPY ON 13C, 15N-LABELED FLAG-P7. STRUCTURES ARE FROM MEMBRANE CS ROSETTA REFINED WITH NOES IN ARIA 2
REFINED FROM AN INITAL TEMPLATE STRUCTURE FROM CS MEMBRANE ROSETTA ALL NOES ASSIGNED AUTOMATICALLY
SHEN,VERNON,BAKER,BAX,RIEPLING,HABECK, BARDIAUX,BERNARD,MALLIAVIN,NILGES,BRUNGER, ADAMS,CLORE,DELANO,GROS,GROSSE-KUNSTLEVE, JIANG,KUSZEWSKI,NILGES,PANNU,READ,RICE, SIMONSON,WARREN
TRANSPORT PROTEIN, ANTIVIRAL, ION CHANNEL, VIROPORIN