Crystal structure of PPARgamma ligand binding domain in complex with triphenyltin

Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds

Peroxisome proliferator-activated receptor gamma

PPAR-gamma, Nuclear receptor subfamily 1 group C member 3

GPLGSESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRI
FQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFG
DFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTD
LRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

100mM Tris-HCl pH 8.5, 160mM CH3COONH4, 19-23% PEG 4000, VAPOR DIFFUSION, SITTING DROP, temperature 277K

The same protein complexed with trybutyltin

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

protein-ligand complex, DNA-binding, Metal-binding, Nucleus, Receptor, Transcription

ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQ
FRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIV
TEHVQLLQVIKKTETDMSLHPLLQEIYKDLY