Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
DNA (5'-D(*GP*CP*GP*TP*AP*(1TL)P*AP*CP*GP*C)-3')
20 mM sodium cacodylate, 6 mM sodium chloride, 40 mM potassium chloride, 6 mM spermine tetrahydrochloride, 5% v/v MPD, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
diffractometer software from EMBL (with LS-CAT developed extensions)
A-FORM DNA, BICYCLIC NUCLEIC ACID, BNA, DNA, cEt-BNA, ANTISENSE OLIGONUCLEOTIDES