Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor

methyl 4-{[(2Z)-2-cyano-3-hydroxypent-2-enoyl]amino}-4'-fluorobiphenyl-2-carboxylate

Biaryl analogues of teriflunomide as potent DHODH inhibitors.

Dihydroorotate dehydrogenase (quinone), mitochondrial

MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEV
RVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRL
RARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMY
ALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR

ammonium sulfate, pH 4.8, vapor diffusion, temperature 293K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

DHODH, DEHYDROGENASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex