Zn2+-bound FCD domain of TM0439, a putative transcriptional regulator

Integrated Center for Structure and Function Innovation (ISFI)

Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains.

GAMDEKFIRETIETRIMMEVFCLENYFDKIAGSEELLEIKGEIDDVAASAAREIFDDSDERLHKLFIRASGNELIISLYE
KIWDRIDLVRHLNERYVVSNREHKELIERIISGDKEGAIEKLKEHLKNVEAETIKNLYTY

50 mM Tris pH 8.0, 100 mM NaCl, 200 mM (NH4)2SO4, 100 mM BisTris pH 5.5, 25% PEG 3350, 0.1 mM ZnCl2, 2 mM DTT , VAPOR DIFFUSION, SITTING DROP, temperature 277K

Integrated Center for Structure and Function Innovation

Full-length Ni2+-bound structure of Tm0439, a FCD family transcriptional regulator

Full-length metal-free structure of Tm0439, a FCD family transcriptional regulator

Metal-free FCD domain of TM0439 a putative transcriptional regulator (SER mutation E118A, K119A, K122A)

TRANSCRIPTION FACTOR, TRANSCRIPTION, METAL-BINDING, Structural Genomics, PSI-2, Protein Structure Initiative, Integrated Center for Structure and Function Innovation, ISFI, FADR-C, FADR, GNTR, TRANSCRIPTIONAL REGULATOR, TRANSCRIPTION REPRESSOR, ZINC-BINDING, NICKEL-BINDING, DNA-BINDING, SURFACE ENTROPY REDUCTION, TRANSCRIPTION REGULATOR

chain 'A' and (resseq 72:118 or resseq 121:211 ) and (not element H)

chain 'B' and (resseq 72:118 or resseq 121:211 ) and (not element H)

DEKFIRETIETRIMMEVFCLENYFDKIAGSEELLEIKGEIDDVEKSAKREIFDDSDERLHKLFIRASGNELIISLYEKIW
DRIDLVRHLNERYVVSNREHKELIERIISGDKEGAIEKLKEHLKNVEAETIKNLYTY