Crystal structure of human SET domain-containing protein3

Histone-lysine N-methyltransferase setd3

GKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPD
L(MSE)KWASENGASVEGFE(MSE)VNFKEEGFGLRATRDIKAEELFLWVPRKLL(MSE)TVESAKNSVLGPLYSQDRIL
QA(MSE)GNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQ
THPHANKLPLKDSFTYEDYRWAVSSV(MSE)TRQNQIPTEDGSRVTLALIPLWD(MSE)CNHTNGLITTGYNLEDDRCEC
VALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYA(MSE)KAEVLARAGIPTSSVFALHFT
EPPISAQLLAFLRVFC(MSE)TEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDK
SVLKNHDLSVRAK(MSE)AIKLRLGEKEILEKAVKSAAVNREYYRQQ(MSE)EEKAP

GKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPD
LMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHL
LCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTY
EDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEF
VIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLG
DSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEKEILEKAVKS
AAVNREYYRQQMEEKAP

20 % PEG4000, 0.2 M calcium Acetate, 0.1 M sodium cacodalyte, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 297K

Histone-lysine N-methyltransferase setd3 (E.C.2.1.1.43)

SETD3, Histone methyltransferase, histone modification, lysine, post-translational modification, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE