Crystal structure of complement component 1, q subcomponent binding protein, C1QBP

Complement component 1 Q subcomponent-binding protein

GC1q-R protein, Glycoprotein gC1qBP, C1qBP, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, p33

IQKHKTLPKMSGGWELELNGTEAKLVRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKVEEQEPELTSTPNFVVEVIKN
DDGKKALVLDCHYPEDEVGQEDEAESDIFSIREVSFQSTGESEWKDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADE
LVELSTALEHQEYITFLEDLKSFVKSQAHHHHHH

25% peg1500, 0.2 M sodium chloride, 0.1 M HEPES, 5% glycerol, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K

THE ORIGINAL EXPRESSION CONSTRUCT ENCOMPASSED RESIDUES 3-282 OF UNIPROT SEQUENCE Q07021. WE SUSPECT THAT DUE TO INTRAMOLECULAR DNA INTERACTIONS ONLY A SHORTENED SEGMENT WAS AMPLIFIED, POSSIBLY ENCODING THE REPORTED AMINO ACID SEQUENCE

refmac, phenix, coot and the molprobity server were also used during refinement. UNK atoms were refined as water rather than omitted in order to better approximate the properties of these unknown entities.

structural genomics, structural genomics consortium, mitochondrion matrix, complement system, protein-binding, SGC, PROTEIN BINDING

IQKHKTLPKMSGGWELELNGTEAKLVRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKVEEQEPELTSTPNFVVEVIKN
DDGKKALVLDCHYPEDEVGQEDEAESDIFSIREVSFQSTGESEWKDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADE
LVELSTALEHQEYITFLEDLKSFVKSQ